Macrophage Polarization and Human Inflammatory Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 25 September 2024 | Viewed by 50
Special Issue Editor
Interests: macrophage polarization; wound healing; complex systems biology; host–pathogen interactions; metabolic immunomodulation; infectious diseases; multiplex biomarker profiling; myeloid cell heterogeneity
Special Issue Information
Dear Colleagues,
Heterogeneity and functional plasticity are unique characteristics of macrophages. As myeloid-derived cells, macrophages have functional phenotypes in all organs and tissues of the body, from tissue resident macrophages, macrophages derived from circulating monocytes, and microglia in the brain to adipocytes. As a keystone cell in multiple tissues, the dysregulation of macrophages contributes to a diverse number of human inflammatory diseases; however, a comprehensive understanding of the cellular mechanisms, environmental stimuli, and clinical outcomes of this dysregulation remains to be fully established. While most research on macrophages categorizes these cells as either classically activated, pro-inflammatory mediators or alternately activated, anti-inflammatory mediators, recent evidence has clearly demonstrated that this paradigm is flawed and that macrophage functionality is far more complex, warranting deeper investigation. The emergent fields of metabolomics and epigenetics have demonstrated that the key to this plasticity is, in part, mediated through environmental stimulation and these complex mechanisms; with that said, more work is needed to decipher the intricacies of this regulation. In this Special Issue, we welcome submissions from researchers in the field of macrophage plasticity and human inflammatory diseases of original research papers, communications, and review articles on one of the following topics:
- Identification of the cellular mechanisms of macrophage polarization;
- Macrophages’ impact on human inflammatory diseases;
- Innovative diagnostics and therapeutics to treat macrophage-associated human inflammatory disease;
- New animal disease models and insights into macrophage polarization and inflammatory disease;
- Metabolic immunomodulation and contribution to macrophage polarization in human inflammatory disease;
- The epigenetic mechanisms of macrophage polarization in human inflammatory disease;
- Host–pathogen interactions and their impact on macrophage polarization in inflammatory infectious diseases.
Dr. Mary Cloud B. Ammons
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- macrophage polarization
- inflammation
- metabolic immunomodulation
- epigenetics
- in vitro models
- in vivo models
- diagnostics
- therapeutics
- infectious disease
- metabolic disease
