Stem Cell Regenerative Medicine: From Molecular Basis to Translational Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 73
Special Issue Editor
Special Issue Information
Dear Colleagues,
Stem cells are a rare subpopulation defined by the potential to self-renew and differentiate into specific cell types. The functional distinction between stem and progenitor cells is well-established in several tissues, particularly in the blood. There, hematopoietic stem cells preserve their self-renewal potential and reconstitution ability in the bone marrow niche. Bone marrow represents a unique setting in which to examine how stroma influences tissue function. Multiple bone marrow stromal cell types serve as regulators of hematopoiesis, and the dysfunction of some causes myelodysplasia and leukemia.
A population of stem-like cells has been reported to possess the ability to self-renewal, invasion, metastasis, and engraftment of distant tissues. This unique cell subpopulation has been designated as cancer stem cells. Cancer stem cells were first identified in leukemia and the contributions of cancer stem cells to cancer progression have been reported in many different types of cancers. The cancer stem cell hypothesis attempts to explain tumor cell heterogeneity based on the existence of stem cell-like cells within solid tumors.
We encourage the submission of original full research papers as well as review articles dealing with novel mechanistic insights and details of the molecular signatures of stem cell biology. We also encourage the submission of manuscripts that focus on translating basic molecular knowledge to new medical applications in stem cell biology. Articles reporting novel technologies aimed at identifying disease biomarkers are also welcomed.
Topics include, but are not limited to, the following:
- New insights into the molecular mechanisms of stem cell biology;
- Stem cell emerging technologies (e.g., bioinformatics, proteomics, metabolomics, tissue arrays, imaging);
- New molecular biomarkers and profiling of cancer stem cells: diagnosis, prognosis, stratification and efficacy;
- Molecular interactions in the niche, including stem cells, immune cells, and stroma cells;
- Genomic profiling of stem cells, including genetics, epigenetics, and genomic instability;
- Preclinical research leads to novel therapies derived from molecular processes and cellular interactions, including gene therapy, nanomedicine-based therapies, and stem cell-based therapy.
Dr. Dongjun Lee
Guest Editor
Manuscript Submission Information
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Keywords
- adult stem cells
- embryonic stem cells
- induced pluripotent stem cells
- hematopoietic stem cells
- hematological malignancy
- regenerative medicine
- cancer stem cells
- niche
- stem cell therapy
- gene editing
- CRISPR/Cas9
- organoids
