Protein–Protein Interactions of Platelet Receptors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 28 June 2024 | Viewed by 194
Special Issue Editor
Interests: platelet receptor structure; protein–protein interactions; mechanisms of receptor activation; platelet receptor inhibition
Special Issue Information
Dear Colleagues,
Protein–protein interactions of platelet receptors are of paramount importance in the field of hemostasis and thrombosis. They underpin the cellular mechanisms of platelet generation, adhesion, activation and aggregation. These events are initiated by a wide range of platelet receptors with protein ligands including von Willebrand factor, collagen, and fibrin. Having a detailed understanding for these protein–protein interactions is key to understanding how platelets function.
Furthermore, platelet receptor interactions play a major role in pathological conditions such as thrombosis and thrombo-inflammation. Targeting protein–protein interactions is a fundamental approach to developing antiplatelet therapies. Examples of existing drugs that inhibit platelet receptor–protein ligand binding include the glycoprotein IIb/IIIa inhibitors Abciximab, Eptifibatide, and Tirofiban, which block receptor binding to fibrinogen and von Willebrand factor. A variety of platelet receptors have been identified as promising antiplatelet targets that, when inhibited, do not induce increased risks of bleeding. Understanding the nature of these interactions is key to designing specific inhibitors.
The study of protein interactions involving platelet receptors has far-reaching implications, from fundamental biological processes to the development of life-saving medications. This Special Issue, entitled “Protein–Protein Interactions of Platelet Receptors”, will provide an up-to-date description of new and exciting interactions of proteins with platelet receptors.
Dr. Alexandre Slater
Guest Editor
Manuscript Submission Information
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Keywords
- thrombosis
- antiplatelet
- activation
- interaction
- inhibition
