Molecular Biology of Osteoporosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 113
Special Issue Editor
Interests: osteoporosis; bone cells; molecular; cell signalling; therapies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Osteoporosis is one of the most common metabolic bone diseases. Osteoporotic fractures, which represent a growing economic burden on global healthcare systems, impair quality of life and increase morbidity and mortality. In health, bone homeostasis encompasses coordinated dynamic equilibrium between bone-forming cells (osteoblasts) and bone-resorbing cells (osteoclasts). Mechanical stress is crucial for bone homeostasis and decreased mechanical loading is an established cause of bone loss and osteoporosis. Osteocytes, the most abundant and long-lived bone cells, are terminally differentiated osteoblasts that have a mechanosensory role and have emerged as a master regular of bone homeostasis. Osteocytes produce endocrine and paracrine factors, and this activity is regulated by mechanical stress as well as osteotropic factors such as, oestrogen, vitamin D and parathyroid hormone. This Special Issue explores intricate intra- and intercellular molecular signalling in bone cells in health and osteoporosis.
Dr. Harish K. Datta
Guest Editor
Manuscript Submission Information
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Keywords
- osteoporosis
- bone
- signalling
- molecular
- fractures
- endocrine
- paracrine
