Advances in Cell Signaling via Proteolysis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 84
Special Issue Editors
Interests: proteolysis; gut microbiota; microbial metabolites; probiotics; insulin resistance; type 2 diabetes; insulin signaling
Interests: epigenetics; chromatin biology; cancer epigenetics; X-chromosome inactivation; histone mutation; oncohistones
Special Issues, Collections and Topics in MDPI journals
Interests: regulatory mechanisms of membrane trafficking; intercellular membrane fusion; proteolysis; autophagy; skeletal muscle regeneration; molecular functions of hereditary spastic paraplegia (HSP) related genes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cell signaling and proteolysis are two interconnected processes that play crucial roles in various cellular functions and physiological processes. The connection between cell signaling and proteolysis is multifaceted and bidirectional. Proteolysis is often a key step in many signaling pathways, where it acts as a regulatory mechanism to control the activation, duration and intensity of signaling. For example, the proteolytic cleavage of inactive precursor proteins, known as zymogens or proenzymes, can generate active signaling molecules or enzymes. This process is observed in the activation of growth factors, cytokines and transcription factors. Conversely, cell signaling can also regulate proteolysis. The activation of specific signaling pathways can induce changes in the expression, localization or activity of proteases or their inhibitors, thereby modulating proteolytic events. For instance, signaling pathways involved in inflammation can upregulate the expression of proteases, such as matrix metalloproteinases (MMPs), which are involved in tissue remodeling and repair. Furthermore, aberrant or dysregulated proteolysis can lead to disrupted cell signaling and contribute to various diseases. Dysregulated proteases can lead to the excessive degradation of signaling molecules or their receptors, impairing their function and disrupting cellular communication. Similarly, abnormal activation or overexpression of proteases can cause uncontrolled proteolysis, leading to tissue damage, inflammation and pathological conditions.
In summary, cell signaling and proteolysis are interconnected processes that regulate and influence each other. The precise coordination between these processes is crucial for maintaining cellular homeostasis, normal physiological functions and the prevention of disease. Understanding the intricate relationship between cell signaling and proteolysis provides valuable insights into the complexity of cellular processes and offers potential therapeutic targets for various diseases.
This Special Issue focuses on the research field of the proteolysis, and welcomes original research articles, short communications and reviews, both narrative and systematic.
Dr. Hoi Leong Xavier Wong
Dr. Kui Ming Chan
Prof. Dr. Satoshi Kametaka
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cell signaling
- proteolysis
- protease
- cancer
- stem cell
