Molecular Research on the Neurodegenerative Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 198
Special Issue Editors
Interests: molecular pathogenesis of neurodegeneration; Huntington’s disease; Alzheimer’s disease; transcriptomics; miRNAs; epigenetic regulation of transcription; histone variants and histone modifications; animal models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases are severe conditions that cause cognitive decline, psychiatric symptoms, and/or movement disturbances, potentially culminating in fatality. Considering that age is a pivotal risk factor in the prevalent types of these disorders, their occurrence is expected to rise with the increasing life expectancy of today’s aging populations. Projections suggest that the global number of individuals affected by dementia will surpass 60 million by 2030 and exceed 110 million by 2050. Consequently, these disorders pose a substantial and growing health and economic burden.
The most common neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease, typically occur sporadically, while others follow an inherited Mendelian pattern. However, it can generally be stated that the pathomechanisms of neurodegenerative disorders are complex, encompassing numerous fundamental biological processes at the molecular and cellular levels. These affected processes include, among others, proteostasis, transcription, mitochondrial function, and intra- and intercellular signalling. An enhanced understanding of the roles played by these molecular mechanisms in pathology is crucial when aiming to develop much-needed causative therapies.
The objective of this Special Issue is to spotlight recent advances in investigating the molecular basis of neurodegenerative disorders’ pathology and explore the potential therapeutic applications of these mechanisms. We welcome the submission of original scientific research and review articles for this Special Issue.
Dr. Laszlo Bodai
Dr. Nora Zsindely
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurodegeneration
- neurodegenerative disorders
- Alzheimer’s disease
- Parkinson’s disease
- polyglutamine diseases
- amyotrophic lateral sclerosis
- multiple sclerosis
- molecular pathomechanisms
- pathogenesis
