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Molecular and Electrophysiological Modulation in Cardiac Arrhythmias

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 118

Special Issue Editor

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Carlos IIIMelchor Fernández Almagro, 328029 Madrid, Spain
Interests: electrophysiology; inheritable cardiac diseases; cardiac arrhythmias; ion channels; molecular biology; cellular biology; pharmacology; animal models; iPSC-CMs
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Special Issue Information

Dear Colleagues,

Cardiac arrhythmias are prevalent diseases among humans at different ages and may occur in diseased and structurally normal hearts. While arrhythmias have widely varied phenotypes and causes (automaticity, triggered activity, and re-entry), they possess shared cellular electrophysiologic properties. These involve abnormalities in action potential generation, repolarization, or conduction due to a complex interplay of ion channels and their intracellular regulation, as well as electrophysiological remodelling. Thus, increasing the knowledge of the molecular and electrophysiological mechanisms of arrhythmia may be critical to the development of an appropriate diagnosis and treatment strategy.

In this Special Issue, experts in the field will update the readers on the role of ion channel and their molecular biology in normal cardiac electrical function and the mechanisms of arrhythmias leading to sudden cardiac death from the bench to the clinic. The articles will focus on the current knowledge, important questions that remain unanswered, and future research to develop an advance therapy for inheritable and acquired ion-channel-related diseases.

Dr. Álvaro Macias
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • arrhythmias
  • cardiac electrophysiology
  • molecular biology
  • ion channels
  • intracellular regulation
  • intracellular calcium dynamics
  • trafficking
  • post-translational modifications
  • structural alterations
  • gene expression
  • animal models
  • basic, translational and clinical science

Published Papers

This special issue is now open for submission.
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