Molecular and Electrophysiological Modulation in Cardiac Arrhythmias
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 May 2024 | Viewed by 221
Special Issue Editor
Interests: electrophysiology; inheritable cardiac diseases; cardiac arrhythmias; ion channels; molecular biology; cellular biology; pharmacology; animal models; iPSC-CMs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiac arrhythmias are prevalent diseases among humans at different ages and may occur in diseased and structurally normal hearts. While arrhythmias have widely varied phenotypes and causes (automaticity, triggered activity, and re-entry), they possess shared cellular electrophysiologic properties. These involve abnormalities in action potential generation, repolarization, or conduction due to a complex interplay of ion channels and their intracellular regulation, as well as electrophysiological remodelling. Thus, increasing the knowledge of the molecular and electrophysiological mechanisms of arrhythmia may be critical to the development of an appropriate diagnosis and treatment strategy.
In this Special Issue, experts in the field will update the readers on the role of ion channel and their molecular biology in normal cardiac electrical function and the mechanisms of arrhythmias leading to sudden cardiac death from the bench to the clinic. The articles will focus on the current knowledge, important questions that remain unanswered, and future research to develop an advance therapy for inheritable and acquired ion-channel-related diseases.
Dr. Álvaro Macias
Guest Editor
Manuscript Submission Information
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Keywords
- arrhythmias
- cardiac electrophysiology
- molecular biology
- ion channels
- intracellular regulation
- intracellular calcium dynamics
- trafficking
- post-translational modifications
- structural alterations
- gene expression
- animal models
- basic, translational and clinical science
