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Neurotrauma and Health

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Global Health".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 20946

Special Issue Editors


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Guest Editor
Department of Neurosurgery, Azienda Ospedaliera Universitaria Pisana (AOUP), University of Pisa, 56010 Pisa, Italy
Interests: brain tumor; glioblastoma multiforme; low-grade glioma; meningioma; schwannoma; augmented reality; tractography; neurosurgery
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Guest Editor
Department of Translational Research and of New Surgical and Medical Technologies; University of Pisa, 56010 Pisa, Italy;Department of Neurosurgery, Azienda Ospedaliera Universitaria Pisana (AOUP), 56010 Pisa, Italy
Interests: neurosurgery; spine surgery; brain tumor; neuroanatomy; trigeminal neuralgia; subarachnoid hemorrhage; cerebrovascular disease; craniocervical junction; hydrocephalus

Special Issue Information

Dear Colleagues,

Neurotrauma is a critical public health problem that deserves the attention of the world's health community. Estimates of brain and spinal cord injury occurrence indicate that these injuries cause enormous losses to individuals, families and communities. They result in a large number of deaths and impairments leading to permanent disabilities.

Neurotrauma refers to injuries that involve the brain, nerves or spine. Neurotrauma is an emergency for which it is important to seek treatment immediately. Traumatic brain or spine injuries lead to intensive care hospitalization or surgical treatment, but they can have long-lasting effects, including cognitive impairment, nerve damage, leaking spinal fluid, pain and posttraumatic stress disorder.

Traumatic brain injury can cause long-term physical disability and complex neuro-behavioral effects, which disrupt quality of life, employment prospects and interpersonal relationships. Spinal cord injury can also cause long-term physical disability and complex complications, which disrupt quality of life, including limiting physical and social mobility, psychological complications (depression and suicide) and medical complications, often due to autonomic nervous system dysfunction.

This Special Issue will explore the public health implications and epidemiology of brain and spine trauma, explore emerging research and innovative strategies to reduce morbidity and mortality, report clinical series reporting surgical, medical and rehabilitation treatments and highlight best practices to address physicians. We welcome original papers, systematic reviews, meta-analyses, clinical images and thorough reviews on this interesting topic.

This Special Issue aims to provide a complex source of up-to-date data used by emergency physicians, neurosurgeons, anesthesiologists, orthopedists, maxillofacial surgeons, radiologists, neurologists, psychiatrists, critical care specialists, rehabilitation physicians and neuropsychologists.

We invite you to submit articles on topics including, but not limited to, the following:

  • Traumatic brain injury
  • Penetrating brain injury
  • Depressed skull fracture
  • Craniofacial trauma
  • Epidural and subdural hematoma
  • Traumatic subarachnoid hemorrhage
  • Traumatic intracerebral hemorrhage/brain contusion
  • Spinal cord injury
  • Craniocervical spine injury
  • Cervical spine injury
  • Thoracolumbar spine injury
  • Traumatic spondylolisthesis
  • Neuroimaging
  • Peripheral nervous system
  • Supportive care
  • Posttraumatic rehabilitation
  • Neurotrauma
  • Pain
  • Critical care medicine
  • Cognitive impairment
  • Posttraumatic stress disorder

Dr. Nicola Montemurro
Prof. Dr. Paolo Perrini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • injuries
  • traumatic brain injury
  • spine injury
  • prevention and diagnosis
  • risk factors
  • elderly patients
  • polytrauma
  • critical care medicine
  • sport injuries
  • rehabilitation
  • craniofacial trauma
  • neurosurgery
  • peripheral nervous system
  • posttraumatic rehabilitation
  • pain
  • neuroimaging
  • critical care medicine
  • cognitive impairment
  • posttraumatic stress disorder
  • supportive care.

Published Papers (8 papers)

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14 pages, 2311 KiB  
Article
Patient Outcomes following Immediate Tracheostomy and Emergency Decompressive Craniectomy in the Same Setting
by Ramesh Kumar, Mohd Sofan Zenian, Tang Yiu Maeng, Farizal Fadzil and Anis Nabillah Mohd Azli
Int. J. Environ. Res. Public Health 2022, 19(23), 15746; https://doi.org/10.3390/ijerph192315746 - 26 Nov 2022
Viewed by 1499
Abstract
Early tracheostomy is recommended for patients with severe traumatic brain injury or stroke. Tracheostomy in the same setting as emergency decompressive craniectomy, on the other hand, has never been investigated. Our goal was to compare the outcomes related to the duration of mechanical [...] Read more.
Early tracheostomy is recommended for patients with severe traumatic brain injury or stroke. Tracheostomy in the same setting as emergency decompressive craniectomy, on the other hand, has never been investigated. Our goal was to compare the outcomes related to the duration of mechanical ventilation in patients who had immediate (IT) vs. early (ET) tracheostomy following an emergency decompressive craniectomy in a Neurosurgical centre in Sabah, Malaysia. We reviewed 135 patients who underwent emergency decompressive craniectomy for traumatic brain injury (TBI) and stroke patients between January 2013 and January 2018 in this retrospective cohort study. The cohort included 49 patients who received immediate tracheostomy (IT), while the control group included 86 patients who received a tracheostomy within 7 days of decompressive surgery (ET). The duration of mechanical ventilation, length of stay (LOS) in the critical-care unit, and intravenous sedation were significantly shorter in the IT group compared to the ET group, according to the study. There was no significant difference between the two groups in the incidence of ventilator-associated pneumonia (VAP), tracheostomy-related complications, or 30-day mortality rate. In conclusion, compared to early tracheostomy, immediate tracheostomy in the same setting as emergency decompressive craniectomy is associated with a shorter duration of mechanical ventilation and LOS in critical-care units with acceptable morbidity and mortality rates. This practise could be used in busy centres with limited resources, such as those where mechanical ventilators, critical-care unit beds, or OT wait times are an issue. Full article
(This article belongs to the Special Issue Neurotrauma and Health)
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11 pages, 785 KiB  
Article
Value of Repeat CT Brain in Mild Traumatic Brain Injury Patients with High Risk of Intracerebral Hemorrhage Progression
by Farizal Fadzil, Amy Khor Cheng Mei, Azudin Mohd Khairy, Ramesh Kumar and Anis Nabillah Mohd Azli
Int. J. Environ. Res. Public Health 2022, 19(21), 14311; https://doi.org/10.3390/ijerph192114311 - 02 Nov 2022
Cited by 3 | Viewed by 2314
Abstract
Patients with mild traumatic brain injury (MTBI) with intracerebral hemorrhage (ICH), particularly those at higher risk of having ICH progression, are typically prescribed a second head Computer Tomography (CT) scan to monitor the disease development. This study aimed to evaluate the role of [...] Read more.
Patients with mild traumatic brain injury (MTBI) with intracerebral hemorrhage (ICH), particularly those at higher risk of having ICH progression, are typically prescribed a second head Computer Tomography (CT) scan to monitor the disease development. This study aimed to evaluate the role of a repeat head CT in MTBI patients at a higher risk of ICH progression by comparing the intervention rate between patients with and without ICH progression. Methods: 192 patients with MTBI and ICH were treated between November 2019 to December 2020 at a single level II trauma center. The Glasgow Coma Scale (GCS) was used to classify MTBI, and initial head CT was performed according to the Canadian CT head rule. Patients with a higher risk of ICH progression, including the elderly (≥65 years old), patients on antiplatelets or anticoagulants, or patients with an initial head CT that revealed EDH, contusional bleeding, or SDH > 5 mm, and multiple ICH underwent a repeat head CT within 12 to 24 h later. Data regarding types of intervention, length of stay in the hospital, and outcome were collected. The risk of further neurological deterioration and readmission rates were compared between these two groups. All patients were followed up in the clinic after one month or contacted via phone if they did not return. Results: 189 patients underwent scheduled repeated head CT, 18% had radiological intracranial bleed progression, and 82% had no changes. There were no statistically significant differences in terms of intervention rate, risk of neurological deterioration in the future, or readmission between them. Conclusion: Repeat head CT in mild TBI patients with no neurological deterioration is not recommended, even in patients with a higher risk of ICH progression. Full article
(This article belongs to the Special Issue Neurotrauma and Health)
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10 pages, 1281 KiB  
Article
Surgical Treatment of Long-Standing Overt Ventriculomegaly in Adults (LOVA): A Comparative Case Series between Ventriculoperitoneal Shunt (VPS) and Endoscopic Third Ventriculostomy (ETV)
by Nicola Montemurro, Antonino Indaimo, Davide Tiziano Di Carlo, Nicola Benedetto and Paolo Perrini
Int. J. Environ. Res. Public Health 2022, 19(4), 1926; https://doi.org/10.3390/ijerph19041926 - 09 Feb 2022
Cited by 12 | Viewed by 2020
Abstract
Background: Long-standing overt ventriculomegaly in adults (LOVA) is an uncommon type of adult chronic hydrocephalus. In recent years, conflicting case series described different outcomes after treatment of LOVA with endoscopic third ventriculostomy (ETV) or ventriculoperitoneal shunt (VPS). The aim of this study is [...] Read more.
Background: Long-standing overt ventriculomegaly in adults (LOVA) is an uncommon type of adult chronic hydrocephalus. In recent years, conflicting case series described different outcomes after treatment of LOVA with endoscopic third ventriculostomy (ETV) or ventriculoperitoneal shunt (VPS). The aim of this study is to report a single institutional surgical experience of patients with LOVA in order to evaluate the clinical outcome of those patients treated with one or, sometimes, both surgical procedures, analyzing the main clinical features of these patients, before and after surgery. Methods: We conducted a retrospective study on 31 patients with diagnosis of LOVA, who were treated in our University Hospital between December 2010 and October 2020. We reported gender, age, clinical presentation, surgical treatment, and clinical outcome according to the Kiefer index (KI). Evans’ index, head circumference, aqueductal stenosis and expanded/destroyed sella turcica were assessed on preoperative MRI. Results: The most common clinical manifestation was gait disturbances (100%) followed by urinary incontinence in 23 (74.2%) patients and cognitive deficits in 22 (71%) patients. On preoperative MRI, the overall mean Evans’s Index was 0.49, whereas the overall mean head circumference was 57.3 cm. Twenty-three patients (74.2%) had obliterated cortical sulci, 20 (64.5%) patients had aqueductal stenosis, and 22 (71%) patients had an expanded/destroyed sella turcica on preoperative MRI. Fifteen (48.4%) patients underwent ETV and sixteen (51.6%) were treated with VPS as first surgical procedure. Four (26.6%) out of fifteen patients treated with ETV required a subsequent VPS. The overall median age of patients was 64 (IQR: 54.5–74) and the overall median follow-up was 57 months (IQR 21.5–81.5). Overall morbidity was 22.5%. Mean recovery index (RI), according to KI, was 3.8 ± 4.3 and 2.2 ± 5.6 (p = 0.05) at last follow-up in patients treated with ETV and VPS, respectively. Conclusions: The choice of surgical treatment of LOVA remains under discussion. Although EVT is a tempting option for patients with LOVA, conversion to VP shunt is not uncommon. Full article
(This article belongs to the Special Issue Neurotrauma and Health)
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13 pages, 356 KiB  
Article
Quality of Life and Physical Activity of Persons with Spinal Cord Injury
by Tjasa Filipcic, Vedrana Sember, Maja Pajek and Janez Jerman
Int. J. Environ. Res. Public Health 2021, 18(17), 9148; https://doi.org/10.3390/ijerph18179148 - 30 Aug 2021
Cited by 12 | Viewed by 2643
Abstract
The higher quality of life of people with spinal cord injury is closely related with their reintegration into the social environment. Social reintegration is a demanding and complex process, requiring individuals to become active again and acquire age-, gender-, and culture-appropriate roles and [...] Read more.
The higher quality of life of people with spinal cord injury is closely related with their reintegration into the social environment. Social reintegration is a demanding and complex process, requiring individuals to become active again and acquire age-, gender-, and culture-appropriate roles and social status. It also involves independence and productive behavior as part of multiple interpersonal relationships with family, friends, and others. In order to establish whether individuals with spinal cord injury who are physically active subjectively rate their quality of life to be higher compared to those who are not, sixty-two respondents from Slovenia with spinal cord injury were interviewed. Thirty-one of them were physically active, and 31 were not. The level of injury of the responders was from Th6–Th12. The participants gave the highest assessments to their interpersonal relationships, and the lowest to their satisfaction with material prosperity. Data comparison showed that subjective estimates in all areas of quality of life are higher in respondents who were involved in physical activity after their injury. The results may encourage persons with spinal cord injury to participate more often in sports programs, and also encourage others to do so. Full article
(This article belongs to the Special Issue Neurotrauma and Health)
11 pages, 1961 KiB  
Article
Reducible Nonunited Type II Odontoid Fracture with Atlantoaxial Instability: Outcomes of Two Different Fixation Techniques
by Torphong Bunmaprasert, Vorapop Trirattanapikul, Nantawit Sugandhavesa, Areerak Phanphaisarn, Wongthawat Liawrungrueang and Phichayut Phinyo
Int. J. Environ. Res. Public Health 2021, 18(15), 7990; https://doi.org/10.3390/ijerph18157990 - 28 Jul 2021
Cited by 6 | Viewed by 5194
Abstract
Displaced nonunited type II odontoid fracture can result in atlantoaxial instability, causing delayed cervical myelopathy. Both Magerl’s C1-C2 transarticular screw fixation technique and Harms-Goel C1-C2 screw-rod segmental fixation technique are effective techniques to provide stability. This study aimed to demonstrate the results of [...] Read more.
Displaced nonunited type II odontoid fracture can result in atlantoaxial instability, causing delayed cervical myelopathy. Both Magerl’s C1-C2 transarticular screw fixation technique and Harms-Goel C1-C2 screw-rod segmental fixation technique are effective techniques to provide stability. This study aimed to demonstrate the results of two surgical fixation techniques for the treatment of reducible nonunited type II odontoid fracture with atlantoaxial instability. Medical records of patients with reducible nonunited type II odontoid fracture hospitalized for spinal fusion between April 2007 and April 2018 were reviewed. For each patient, specific surgical fixation, either Magerl’s C1-C2 transarticular screw fixation technique augmented with supplemental wiring or Harms-Goel C1-C2 screw-rod fixation technique, was performed according to our management protocol. We reported the fusion rate, fusion period, and complications for each technique. Of 21 patients, 10 patients were treated with Magerl’s C1-C2 transarticular screw fixation technique augmented with supplemental wiring, and 11 were treated with Harms-Goel C1-C2 screw-rod fixation technique. The bony fusion rate was 100% in both groups. The mean time to fusion was 69.7 (95%CI 53.1, 86.3) days in Magerl’s C1-C2 transarticular screw fixation technique and 75.2 (95%CI 51.8, 98.6) days in Harms-Goel C1-C2 screw-rod fixation technique. No severe complications were observed in either group. Displaced reducible, nonunited type II odontoid fracture with cervical myelopathy should be treated by surgery. Both fixation techniques promote bony fusion and provide substantial construct stability. Full article
(This article belongs to the Special Issue Neurotrauma and Health)
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10 pages, 632 KiB  
Article
Secular Trend, Seasonal Variation, Epidemiological Pattern, and Outcome of Traumatic Head Injuries Due to Road Traffic Accidents in Aseer, Saudi Arabia
by Mubarak Ali Algahtany
Int. J. Environ. Res. Public Health 2021, 18(12), 6623; https://doi.org/10.3390/ijerph18126623 - 20 Jun 2021
Cited by 8 | Viewed by 2736
Abstract
Road traffic accidents (RTAs) are a leading cause of traumatic head injury (THI) and are regarded as a public health problem in Saudi Arabia. This hospital-based retrospective study aims to provide data on the frequency, type, and distribution of RTA-related THIs over the [...] Read more.
Road traffic accidents (RTAs) are a leading cause of traumatic head injury (THI) and are regarded as a public health problem in Saudi Arabia. This hospital-based retrospective study aims to provide data on the frequency, type, and distribution of RTA-related THIs over the past decade; demonstrate their time trend and seasonality; and decipher age and sex differences in RTA-related THIs and their outcome. The results showed a decline in the number of RTA-related THIs between 2010 and 2019. The patients had a mean age of 26.16 ± 16.27 years, and the male-to-female ratio was 10.8:1. Head injury with multiple lesions was the most common diagnosis, followed by cerebral contusion and skull fracture (32.1%, 12.9%, and 11.2%, respectively). Subdural hematoma (SDH) and skull fracture were significantly more common in patients aged ≥60 years (standard residual > 1.96), and significantly less common in those aged ≤17 years (standard residual < 1.96), compared to other age groups. Males experienced significantly more SDHs than females (standard residual = −2.8, p = 0.029). The length of hospital stay was positively correlated with age (Spearman’s rho = 0.057, p = 0.046). No seasonal variation was found. Full article
(This article belongs to the Special Issue Neurotrauma and Health)
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2 pages, 248 KiB  
Comment
Comment on Bunmaprasert et al. Reducible Nonunited Type II Odontoid Fracture with Atlantoaxial Instability: Outcomes of Two Different Fixation Techniques. Int. J. Environ. Res. Public Health 2021, 18, 7990
by Ayhan Kanat
Int. J. Environ. Res. Public Health 2022, 19(9), 5018; https://doi.org/10.3390/ijerph19095018 - 20 Apr 2022
Cited by 4 | Viewed by 1125
Abstract
I read with great interest the paper of Bunmaprasert et al. [...] Full article
(This article belongs to the Special Issue Neurotrauma and Health)
7 pages, 1044 KiB  
Case Report
Massive Edema of the Lower Limbs in Patients after Spinal Cord Injury—One Picture, Different Diagnoses
by Magdalena Mackiewicz-Milewska, Małgorzata Cisowska-Adamiak, Katarzyna Sakwińska, Iwona Szymkuć-Bukowska and Iwona Głowacka-Mrotek
Int. J. Environ. Res. Public Health 2021, 18(8), 4219; https://doi.org/10.3390/ijerph18084219 - 16 Apr 2021
Cited by 1 | Viewed by 2317
Abstract
Diagnosis of the cause of massive edema of the lower limbs in patients after spinal cord injury (SCI) can be difficult because of loss of pain sensation, commonly occurring in this group of patients. This paper reviews several different pathologies that can lead [...] Read more.
Diagnosis of the cause of massive edema of the lower limbs in patients after spinal cord injury (SCI) can be difficult because of loss of pain sensation, commonly occurring in this group of patients. This paper reviews several different pathologies that can lead to lower-limb edema and the associated diagnostic difficulties. We present four cases of patients with massive edemas of lower limbs at different times after SCI undergoing treatment in the Department of Rehabilitation, University Hospital in Bydgoszcz, Poland. All patients had a lack of pain sensation in the lower limbs and significantly elevated levels of D-dimer. In two cases, deep vein thrombosis (DVT) and intramuscular hematomas (IHs) were diagnosed. IHs were probably a consequence of antithrombotic treatments implemented due to the occurrence of DVT. Heterotopic ossification (HO) was diagnosed in a third case, and, in another patient, who was hospitalized for the longest period after injury, we found humeral bone fractures. Heterotopic ossification, intramuscular haematomas, and bone fractures of the lower limb can mimic DVT. Careful observation of the edema evolution is recommended, as the onset of new symptoms may indicate a different cause of edema from that initially established. Full article
(This article belongs to the Special Issue Neurotrauma and Health)
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