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Inter-organ Cross-Talk in Critical Illness and Perioperative Medicine

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Communication and Informatics".

Deadline for manuscript submissions: closed (30 March 2023) | Viewed by 1698

Special Issue Editor


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Guest Editor
Department of Anaesthesiology and Intensive Care, Medical University of Silesia, 40-055 Katowice, Poland
Interests: intensive care medicine; perioperative medicine; neurocritical care; hemodynamics; sepsis; fluids
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There is growing number of scientific data confirming the role of inter-organ relations in critical illness. The more we know about this interesting between-organ crosstalk, the more personalized monitoring and therapy can be applied to the patients in need who are hospitalized in intensive care units. Now we are aware of the fact that no single injury of the central nervous system exists without its multidimensional impact on the heart, lungs, kidneys, or gut. The same theory may be extrapolated on the understanding of the role of acute lung injury or acute heart failure. The is ongoing debate how frequent is this type of interference, what is its extent inside the body and what sequelae it may generate, also in the follow-up observation. Moreover, patients in the perioperative period, who are at the highest risk of postoperative complications due to persistent significant abnormalities in their homeostasis, may also benefit from implementation of the goal-directed therapy, basing on their inter-organ crosstalk.

Therefore, I would invite you to participate in this interesting scientific project. If your study relates to this interesting issue, feel free to submit a report, preferably original, describing current knowledge and future directives. I hope that this Special Issue will help anesthetists and intensivists to improve perioperative and intensive care in the future.

Prof. Dr. Łukasz Krzych
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute heart failure
  • acute lung injury
  • subarachnoid hemorrhage
  • intracranial bleeding
  • acute kidney injury
  • sepsis
  • hematological abnormalities
  • microbiota
  • intensive care medicine
  • perioperative medicine
  • inter-organ crosstalk
  • complications
  • monitoring
  • therapy

Published Papers (1 paper)

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Research

13 pages, 1559 KiB  
Article
The Role of Plasminogen Activator Inhibitor 1 in Predicting Sepsis-Associated Liver Dysfunction: An Observational Study
by Ewa Woźnica-Niesobska, Patrycja Leśnik, Jarosław Janc, Małgorzata Zalewska and Lidia Łysenko
Int. J. Environ. Res. Public Health 2023, 20(6), 4846; https://doi.org/10.3390/ijerph20064846 - 9 Mar 2023
Viewed by 1268
Abstract
Sepsis-associated liver dysfunction (SALD) is associated with a poor prognosis and increased mortality in the intensive care unit. Bilirubin is one of the components of Sequential Organ Failure Assessment used in Sepsis-3 criteria. Hyperbilirubinemia is a late and non-specific symptom of liver dysfunction. [...] Read more.
Sepsis-associated liver dysfunction (SALD) is associated with a poor prognosis and increased mortality in the intensive care unit. Bilirubin is one of the components of Sequential Organ Failure Assessment used in Sepsis-3 criteria. Hyperbilirubinemia is a late and non-specific symptom of liver dysfunction. This study aimed to identify plasma biomarkers that could be used for an early diagnosis of SALD. This prospective, observational study was conducted on a group of 79 patients with sepsis and septic shock treated in the ICU. Plasma biomarkers—prothrombin time, INR, antithrombin III, bilirubin, aspartate transaminase (AST), alanine transaminase, alkaline phosphatase, gamma glutamyl transferase, albumin, endothelin-1, hepcidin, plasminogen activator inhibitor-1 (PAI-1), thrombin-antithrombin complex, and interferon-gamma inducible protein (10 kDa) were analysed. Plasma samples were obtained within 24 h after having developed sepsis/septic shock. Enrolled patients were followed for 14 days for developing SALD and 28 days for overall survival. A total of 24 patients (30.4%) developed SALD. PAI-1 with a cut-off value of 48.7 ng/mL was shown to be a predictor of SALD (AUC = 0.671, sensitivity 87.3%, and specificity 50.0%) and of 28-day survival in patients with sepsis/septic shock (p = 0.001). Measuring PAI-1 serum levels at the onset of sepsis and septic shock may be useful in predicting the development of SALD. This should be verified in multicenter prospective clinical trials. Full article
(This article belongs to the Special Issue Inter-organ Cross-Talk in Critical Illness and Perioperative Medicine)
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