Special Issue "Molecular Genetics & Diagnosis of Infectious Diseases"
Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 6733
Interests: molecular techniques; infectious disease; prevalence; regional and global
Interests: culture; viral; sequencing; disease
Infectious diseases pose a noteworthy public health risk, and infectious disease epidemics can have significant community, political, and economic costs. Historical outbreak conditions offer ways for designing an effective response to infectious disease events. In such circumstances, molecular diagnostics have important applications in screening and confirmation of asymptomatic infections, such as through syndromic therapy.
The first step to counter an infection is correct diagnosis, which depends upon important parameters such as assay sensitivity and specificity. These parameters can be used in the evaluation of a newly developed technique, after comparison with a reference gold standard method, to differentiate among the true positive and true negative.
In the last two decades, nucleic acid-based approaches have focused on the detection of either a single pathogen or multiple pathogens in a multiplex assay format, previously identified through culture, electron microscopy and immunological techniques. Now, the availability of bench-top sequencers, portable bench-top sequencers, rapid analytical software, on-chip RT-PCR, RT-LAMP, RT-qPCR, NASBA, fluorescence in situ hybridization (FISH), NGS and WGS has helped these methods become user friendly and less complex at a reduced cost, while also having increased sensitivity and specificity. In addition, they have the added benefit of detecting drug resistance genes, quantitative indications under therapy and the emergence of resistant strains.
Prof. Dr. Abrar Hussain
Dr. Irshad ur Rehman
Manuscript Submission Information
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- molecular techniques