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Gastroenterology Insights
Special Issues
Colorectal Cancer: From Molecular Mechanisms to Therapy Strategies
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Colorectal Cancer: From Molecular Mechanisms to Therapy Strategies

A special issue of Gastroenterology Insights (ISSN 2036-7422). This special issue belongs to the section "Gastrointestinal Disease".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1622

Special Issue Editor

Dr. Shing Yau Tam

E-Mail Website
Guest Editor
School of Medical and Health Science, Tung Wah College, Hong Kong, China
Interests: colorectal cancer; radiotherapy; chemotherapy; hypoxia; tumor microenvironment; radiography

Special Issue Information

Dear Colleagues,

Colorectal cancer is one of the most common cancers in the world, ranking third with 1.93 million new cases in 2020. Standard treatment modalities for colorectal cancer include surgery, radiotherapy and chemotherapy. Despite the advancement of these treatment modalities, metachronous metastasis is a major mortality cause; the estimation is that 50% of colorectal cancer patients will develop metastasis in their lifetime. Treatment resistance is common among advanced stage colorectal tumors. Thus, novel research in the field of molecular mechanisms for colorectal cancer development, metastasis and treatment resistance is highly warranted. Additionally, the post-treatment complications of colorectal cancer are less commonly documented than other common cancers such as breast cancer. The investigation into post-treatment patient needs and the reviewing of current clinical practices regarding post-treatment care are important areas for improving quality of life among this large population of colorectal cancer patients.

This Special Issue was established to prompt research in these fields. All types of original research, including basic studies, translational studies and clinical studies, are welcomed. Reviews on the important issues will also be appreciated.

Dr. Shing Yau Tam
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gastroenterology Insights is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal cancer
  • molecular mechanism
  • chemotherapy
  • radiotherapy
  • surgery
  • metastasis
  • treatment resistance
  • post-treatment complications

Published Papers (1 paper)

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Research

11 pages, 1871 KiB  
Article
Comparison of Point Shear Wave Elastography and 2-Dimensional Shear Wave Elastography Values of Liver Metastases from Colorectal Cancer
by Emiliya Lyubomirova Nacheva-Georgieva, Daniel Ilianov Doykov, Bozhidar Krasimirov Hristov, Katya Angelova Doykova and Mladen Ilianov Doykov
Gastroenterol. Insights 2023, 14(3), 271-281; https://doi.org/10.3390/gastroent14030019 - 03 Jul 2023
Cited by 1 | Viewed by 1203
Abstract
Nowadays ultrasound-based non-invasive techniques for the evaluation of tissue elasticity are becoming increasingly popular. A key determinant for the adequate treatment of focal liver lesions is on establishment of accurate diagnosis. Contemporary imaging modalities, particularly ultrasonographic, are widely accepted for assessing the elasticity [...] Read more.
Nowadays ultrasound-based non-invasive techniques for the evaluation of tissue elasticity are becoming increasingly popular. A key determinant for the adequate treatment of focal liver lesions is on establishment of accurate diagnosis. Contemporary imaging modalities, particularly ultrasonographic, are widely accepted for assessing the elasticity of focal liver lesions but the investigation of their accuracy and differentiation potential is still ongoing. Aim: To compare the values of point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) for liver metastases from colorectal cancer. Materials and Methods: A total of 31 adult patients with liver metastases from colorectal cancer (CRC) were included from the Department of Gastroenterology of University Hospital Kaspela, Plovdiv, Bulgaria, in the period June 2022 to November 2022. The men/women ratio of the participants was respectively 11 women and 20 men. For all of them point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) were performed to evaluate the stiffness of liver metastases, by measuring the shear wave velocity (SWV) in a region of interest (ROI). Prior histological confirmation of colorectal cancer through diagnostic lower endoscopy was a prerequisite for inclusion in the study. Contrast-enhanced computer tomography (CECT) was used as a reference imaging modality to confirm the presence of lesions in the liver. All the images were evaluated by a radiologist with long-standing experience in liver imaging. Results: For point shear wave elastography (pSWE), the lower limit was found to be 1.80 m/s (90% CI: 1.39 to 2.32) and the upper limit was 4.21 m/s (90% CI: 3.69 to 4.60). For two-dimensional shear wave elastography (2D-SWE), the lower limit was determined to be 1.87 m/s (90% CI: 1.54 to 2.25) and the upper limit was 3.65 m/s (90% CI: 3.26 to 3.97). Conclusions: Point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) could bring additional information about the stiffness of liver metastases from colorectal cancer but they are not to be considered a method to substitute biopsy of colorectal cancer during lower endoscopy. Full article
(This article belongs to the Special Issue Colorectal Cancer: From Molecular Mechanisms to Therapy Strategies)
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