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Endocrines
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Minimally Invasive Gynecological Surgery for the Management of Infertility
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Minimally Invasive Gynecological Surgery for the Management of Infertility

A special issue of Endocrines (ISSN 2673-396X). This special issue belongs to the section "Female Reproductive System and Pregnancy Endocrinology".

Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 7609

Special Issue Editor

Dr. Osamu Hiraike

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, 113-8655 Japan.
Interests: pathophysiology of the human reproduction and ovary; reproductive endocrinology; benign gynecological tumors; minimally invasive gynecological surgery and endoscopy; repair of pelvic floor; breast cancer; endometrial cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, the treatment of several diseases such as chronic endometritis and cesarean scar syndrome have been proposed to play important roles in improving fertility treatment outcomes. In addition, we should know whether adenomyomectomy prior to the infertility treatment improves the clinical outcome and causes better obstetrical outcomes. These are representative issues that should be solved, but the scope of infertility treatment using minimally invasive techniques has been expanding. Although there still remains room for debate about the diagnostic criteria and standard treatment of these diseases, since a variety of treatment methods have been proposed to be candidates, we would like to expect great progress in this field. Surgical treatment of infertility is expected to make further progress in the future; in this Special Issue, we would like to discuss the development of such devices and treatment modalities, as well as the prospects for future disease treatments and diagnostic techniques that can be utilized.

Prof. Dr. Osamu Hiraike
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Endocrines is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infertility, chronic endometritis, cesarean scar syndrome, adenomyosis
  • laparoscopy/robotic surgery/hysteroscopy
  • preservation of future fertility/diagnosis/treatment

Published Papers (2 papers)

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10 pages, 1964 KiB  
Case Report
Effects of Hydrosalpinx on Endometrial Receptivity and Uterine Microbiome: An Interesting Case of Double Uterus with Unilateral Hydrosalpinx
by Junichiro Mitsui, Kiyotaka Kawai, Makiko Tajima, Kenichiro Hiraoka, Viviane Casaroli, Yoshimi Sato, Yoshiaki Furusawa, Tomonori Ishikawa and Naoyuki Miyasaka
Endocrines 2022, 3(4), 821-830; https://doi.org/10.3390/endocrines3040068 - 12 Dec 2022
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Abstract
Endometrial receptivity array (ERA)—an objective tool used in assisted reproductive technology—is used for personalized embryo transfer in in vitro fertilization. Hydrosalpinx affects implantation through various mechanisms. However, its effects on ERA are not well established. In this case report, we present the diagnosis [...] Read more.
Endometrial receptivity array (ERA)—an objective tool used in assisted reproductive technology—is used for personalized embryo transfer in in vitro fertilization. Hydrosalpinx affects implantation through various mechanisms. However, its effects on ERA are not well established. In this case report, we present the diagnosis and treatment of a 34-year-old nulligravida woman with infertility for two years, obesity, double uterus with unilateral hydrosalpinx and right kidney deficiency. Based on ERA results, endometrial microbiome metagenomic analysis (EMMA), analysis of infectious chronic endometritis (ALICE), and CD138 immunostaining, the patient was treated with hormonal replacement cycle and amoxicillin/clavulanic acid. After one week of amoxicillin/clavulanic acid administration, the vitirified-warmed 4AA blastocyst was transferred to the left uterus—which was absent of hydrosalpinx and easily accessible to transfer and pregnancy was achieved. To the best of our knowledge, this case study is the first one in which we found that there were no differences between the left and right uterus in ERA, EMMA, ALICE, and CD138 immunostainings. Hence, we suggest that hydrosalpinx does not necessarily cause endometrial changes in all cases. Further research to evaluate the effects of hydrosalpinx on implantation with ERA and EMMA/ALICE is warranted. Full article
(This article belongs to the Special Issue Minimally Invasive Gynecological Surgery for the Management of Infertility)
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8 pages, 2772 KiB  
Case Report
Myoma with Hypermenorrhea Treated with Ultrasound-Guided Microwave Ablation of the Inflowing Blood Vessels to the Uterine Myoma: A Case
by Toshiyuki Kakinuma, Takahumi Ohkusa, Takumi Shinohara, Ayano Shimizu, Rora Okamoto, Masataka Kagimoto, Ayaka Kaneko, Kaoru Kakinuma, Kaoru Yanagida, Nobuhiro Takeshima and Michitaka Ohwada
Endocrines 2022, 3(4), 633-640; https://doi.org/10.3390/endocrines3040054 - 13 Oct 2022
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Abstract
Microwave endometrial ablation (MEA) is a minimally invasive treatment for uterine myoma with hypermenorrhea, which can replace conventional hysterectomy. However, cases requiring additional treatment because of postoperative recurrence are often encountered. MEA cauterizes the endometrium and is not recommended for patients who wish [...] Read more.
Microwave endometrial ablation (MEA) is a minimally invasive treatment for uterine myoma with hypermenorrhea, which can replace conventional hysterectomy. However, cases requiring additional treatment because of postoperative recurrence are often encountered. MEA cauterizes the endometrium and is not recommended for patients who wish to preserve fertility. We present the cases of a patient with myoma-related hypermenorrhea who underwent microwave ablation of the inflowing blood vessels to the uterine myoma under transvaginal ultrasound guidance. A 43-year-old woman was diagnosed with chronic myeloid leukemia and treated with dasatinib 2 years ago. Worsening hypermenorrhea was observed after treatment initiation. Ultrasound and pelvic magnetic resonance imaging revealed a uterine myoma. Therefore, she underwent MEA under transvaginal ultrasound guidance. Visual analog scale evaluation demonstrated considerable improvement in hypermenorrhea and dysmenorrhea; the myoma size showed reduction. The postoperative course was uneventful, and the patient was discharged on the day after surgery. No postoperative complications were observed. This patient is currently undergoing infertility treatment. The microwave ablation of myoma under transvaginal ultrasound guidance can effectively and safely reduce the myoma size. These findings suggest that this method is a novel treatment option for patients with myoma-related hypermenorrhea who wish to preserve their fertility and have children. Full article
(This article belongs to the Special Issue Minimally Invasive Gynecological Surgery for the Management of Infertility)
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