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Diagnostics
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Editorial Board Members' Collection Series: The Critical Role of Clinical...
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Editorial Board Members' Collection Series: The Critical Role of Clinical Laboratory for Disease Diagnosis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Laboratory Medicine".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 5154

Special Issue Editors

Prof. Dr. Paul Froom

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Guest Editor
School of Public Health, Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel
Interests: clinical utility; urinary tract infections; elderly, internal medicine; laboratory testing
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Zvi Shimoni

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Guest Editor
1. Department of Internal Medicine B, Laniado Hospital, Netanya 4244916, Israel
2. Ruth and Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel
Interests: laboratory medicine; urinalysis

Special Issue Information

Dear Colleagues, 

We are pleased to announce this collection entitled “Editorial Board Members' Collection Series: The Critical Role of Clinical Laboratory for Disease Diagnosis”. This Issue will comprise a collection of papers by researchers invited by the Editorial Board Members. The aim is to provide a venue for networking and communication between diagnostics and scholars in the field of laboratory medicine. All papers will be fully open access upon publication after peer review.

Prof. Dr. Paul Froom
Prof. Dr. Zvi Shimoni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

13 pages, 2044 KiB  
Article
Elevated Initial Serum Phosphate Levels Predict Higher Mortality and Impaired Neurological Outcome in Cardiac Arrest Patients with Return of Spontaneous Circulation
by Dragos Andrei Duse, Michael Gröne, Nicolas Kramser, Matthias Ortkemper, Christine Quast, Fabian Voß, Nadia Heramvand, Karel Kostev, Malte Kelm, Patrick Horn, Christian Jung and Ralf Erkens
Diagnostics 2023, 13(3), 479; https://doi.org/10.3390/diagnostics13030479 - 28 Jan 2023
Cited by 4 | Viewed by 1230
Abstract
Purpose: Although a moderate proportion of cardiac arrest (CA) patients achieve a return of spontaneous circulation (ROSC), few survive to discharge, mostly with poor neurological development. As serum phosphate levels were described as elevated after cardiopulmonary resuscitation (CPR), we asked whether these elevations [...] Read more.
Purpose: Although a moderate proportion of cardiac arrest (CA) patients achieve a return of spontaneous circulation (ROSC), few survive to discharge, mostly with poor neurological development. As serum phosphate levels were described as elevated after cardiopulmonary resuscitation (CPR), we asked whether these elevations would predict a higher risk of mortality and impaired neurological outcome in CA patients following ROSC. Methods: Initial serum phosphate levels, survival, and neurologic status at discharge of 488 non-traumatic CA patients treated at a single German hospital after achieving ROSC were analyzed. The cut-off value of phosphate for mortality prediction was determined using the receiver operator characteristic (ROC) curve, and patients were divided accordingly for comparison. Results were validated by analyzing phosphate levels in a multi-centric cohort containing 3299 CA patients from the eICU database of the United States. Results: In the German cohort, ROC analysis showed a 90% specificity for phosphate levels >2.7 mmol/L to predict mortality (AUC: 0.76, p < 0.0001), and phosphate level elevations were associated with higher in-hospital mortality (crude odds ratio 3.04, 95% CI 2.32 to 4.08). Patients with initial phosphate levels >2.7 mmol/L had significantly higher mortality in both analyzed collectives (p < 0.0001). Similarly, patients from the German cohort who initially had higher phosphate levels also showed a higher proportion of impaired neurological status at discharge and morphological signs of brain injury. Conclusions: In CA patients following ROSC, initial serum phosphate levels >2.7 mmol/L predict higher mortality and impaired neurological outcome. Our data suggests that phosphate determination might improve the preciseness of the overall and neurologic prognostication in patients after CPR following ROSC. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: The Critical Role of Clinical Laboratory for Disease Diagnosis)
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9 pages, 817 KiB  
Article
Diagnostic Value of Whole-Blood and Plasma Samples in Epstein–Barr Virus Infections
by Mateusz Rzepka, Dagmara Depka, Eugenia Gospodarek-Komkowska and Tomasz Bogiel
Diagnostics 2023, 13(3), 476; https://doi.org/10.3390/diagnostics13030476 - 28 Jan 2023
Cited by 4 | Viewed by 2224
Abstract
Epstein–Barr virus (EBV) is an oncogenic virus classified by the World Health Organization as a class 1 carcinogen. Post-transplant lymphoproliferative disorders are believed to be strongly related to an EBV infection. Monitoring of EBV DNAemia is recommended to assess the risk of reactivation [...] Read more.
Epstein–Barr virus (EBV) is an oncogenic virus classified by the World Health Organization as a class 1 carcinogen. Post-transplant lymphoproliferative disorders are believed to be strongly related to an EBV infection. Monitoring of EBV DNAemia is recommended to assess the risk of reactivation of latent infection and to assess the effectiveness of therapy. Currently, various types of clinical specimens are used for this purpose. The aim of the study was to assess a reliable method of EBV viral load investigation depending on the clinical material used: whole blood or plasma samples. We found that of 134 EBV-DNA-positive whole-blood samples derived from 51 patients (mostly hemato-oncology or post-transplantation), only 43 (32.1%) were plasma-positive. Of these, 37 (86.0%) had lower plasma DNAemia compared to the corresponding whole-blood samples. We conclude that whole-blood samples have a higher sensitivity than plasma samples in EBV DNA detection. The clinical utility of the tests is unclear, but our results suggest that either whole blood or plasma should be used consistently for EBV viral load monitoring. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: The Critical Role of Clinical Laboratory for Disease Diagnosis)
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9 pages, 1187 KiB  
Article
Similar Sensitivity of SARS-CoV-2 Detection in Oropharyngeal/Nasopharyngeal and Saliva Samples on the Hologic Panther Platform
by Ali Vahidnia, Dennis Souverein, Sjoerd M. Euser, Milly Haverkort, Elise Noordhuis, Thomas Z. I. van Zijl, Jayant Kalpoe, Jan C. Sinnige and Bjorn L. Herpers
Diagnostics 2023, 13(3), 347; https://doi.org/10.3390/diagnostics13030347 - 18 Jan 2023
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Abstract
Background: Oropharyngeal (OP) and nasopharyngeal (NP) sampling has historically been considered the reference specimen type used for respiratory virus detection. Saliva could be a less invasive alternative for SARS-CoV-2 detection, but limited evidence is available. Methods: The technical and clinical performance of saliva [...] Read more.
Background: Oropharyngeal (OP) and nasopharyngeal (NP) sampling has historically been considered the reference specimen type used for respiratory virus detection. Saliva could be a less invasive alternative for SARS-CoV-2 detection, but limited evidence is available. Methods: The technical and clinical performance of saliva was compared to OP/NP on the Hologic Panther platform with two Aptima assays, the End-Point Transcription-Mediated Amplification assay (EP-TMA) and Real-Time Transcription-Mediated Amplification assay (RT-TMA). The samples were collected at the Public Health Service Testing Site XL location in Schiphol Amsterdam Airport. At the site, the Regional Public Health Laboratory Kennemerland (RPHLK) has a fully equipped laboratory facility. Results: A total of 374 samples (187 OP/NP swabs and 187 saliva samples) were collected from 187 unique patients. The Real-Time Transcription-Mediated Amplification assay (RT-TMA) resulted in comparable sensitivities for the detection of SARS-CoV-2 in both the OP/NP swabs (88.3%; 113/128) and saliva samples (87.5%; 112/128). The End-Point Transcription-Mediated Amplification assay (EP-TMA) analyses showed a similar sensitivity (86.7%; 111/128) in the OP/NP swabs but a lower sensitivity in the saliva samples (80.5%; 103/128). Within the discordant analyses, we found no associations in the symptoms, earlier SARS-CoV-2 infections and eating, smoking, drinking and tooth brushing habits within one hour before testing. Conclusions: The Hologic Panther platform Real-Time Transcription-Mediated Amplification assay (RT-TMA) yields a sensitivity for the detection of SARS-CoV-2 in saliva that is comparable to the OP/NP swabs derived from participants presenting themselves at a public health testing facility with minimal or mild symptoms. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: The Critical Role of Clinical Laboratory for Disease Diagnosis)
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