Diagnostics and Management of Endometriosis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 7772

Special Issue Editors


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Guest Editor
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Interests: obstetrics and gynecology; gynecological endoscopy; endometriosis

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Guest Editor
Unit of Gynecologic Oncology, ARNAS “Civico—Di Cristina—Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy
Interests: women’s health; gynecological oncology; minimally invasive procedures; up-to-date management; gynecology; reproductive health; surgery
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Guest Editor
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Interests: immunology of heathy and pathologic pregnancy; immunology of gynecologic malignancies; operative gynecology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Although endometriosis is one of the most researched fields, many controversies and debates are still associated with this topic. Affecting women’s health for life, it is a highly important topic for gynecologists specializing in the field. The diagnostics of endometriosis still affect adolescent patients and menopausal women. Less invasive methods and more accurate tests should be discovered for the effective diagnosis. A wide variety of managing methods are available, depending on the age and symptoms of the patients. In infertility clinics, millions of women are found with endometriosis. Fertility preservation treatment and IVF preparation are challenged faced by gynecologists. On the other hand, decreasing the pain as a leading symptom of endometriosis is also integral.

Submissions of reviews and original papers contributing to the advances in the field of diagnostics and the management of endometriosis are encouraged.

Dr. Péter Török
Dr. Antonio Simone Laganà
Dr. Rudolf Lampé
Guest Editors

Manuscript Submission Information

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Keywords

  • endometriosis 
  • infertility 
  • dysmenorrhea 
  • diagnostics 
  • management

Published Papers (2 papers)

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Review

16 pages, 1515 KiB  
Review
Current Understanding of and Future Directions for Endometriosis-Related Infertility Research with a Focus on Ferroptosis
by Hiroshi Kobayashi, Chiharu Yoshimoto, Sho Matsubara, Hiroshi Shigetomi and Shogo Imanaka
Diagnostics 2023, 13(11), 1926; https://doi.org/10.3390/diagnostics13111926 - 31 May 2023
Cited by 5 | Viewed by 1483
Abstract
Background: To date, the development of therapy for endometriosis and disease-related infertility remains a major challenge. Iron overload caused by periodic bleeding is a hallmark of endometriosis. Ferroptosis is an iron- and lipid-reactive oxygen species-dependent type of programmed cell death that is distinct [...] Read more.
Background: To date, the development of therapy for endometriosis and disease-related infertility remains a major challenge. Iron overload caused by periodic bleeding is a hallmark of endometriosis. Ferroptosis is an iron- and lipid-reactive oxygen species-dependent type of programmed cell death that is distinct from apoptosis, necrosis, and autophagy. This review summarizes the current understanding of and future directions for the research and treatment of endometriosis and disease-related infertility, with the main focus on the molecular basis of ferroptosis in endometriotic and granulosa cells. Methods: Papers published between 2000 and 2022 in the PubMed and Google Scholar databases were included in this review. Results: Emerging evidence suggests that ferroptosis is closely linked to the pathophysiology of endometriosis. Endometriotic cells are characterized by ferroptosis resistance, whereas granulosa cells remain highly susceptible to ferroptosis, suggesting that the regulation of ferroptosis is utilized as an interventional target for research into the treatment of endometriosis and disease-related infertility. New therapeutic strategies are urgently needed to efficiently kill endometriotic cells while protecting granulosa cells. Conclusions: An analysis of the ferroptosis pathway in in vitro, in vivo, and animal research enhances our understanding of the pathogenesis of this disease. Here, we discuss the role of ferroptosis modulators as a research approach and potential novel treatment for endometriosis and disease-related infertility. Full article
(This article belongs to the Special Issue Diagnostics and Management of Endometriosis)
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13 pages, 1543 KiB  
Review
Similarities in Pathogenetic Mechanisms Underlying the Bidirectional Relationship between Endometriosis and Pelvic Inflammatory Disease
by Hiroshi Kobayashi
Diagnostics 2023, 13(5), 868; https://doi.org/10.3390/diagnostics13050868 - 24 Feb 2023
Cited by 2 | Viewed by 5777
Abstract
Background: Endometriosis is a common inflammatory disease characterized by the presence of endometrial cells outside of the uterine cavity. Endometriosis affects 10% of women of reproductive age and significantly reduces their quality of life as a result of chronic pelvic pain and infertility. [...] Read more.
Background: Endometriosis is a common inflammatory disease characterized by the presence of endometrial cells outside of the uterine cavity. Endometriosis affects 10% of women of reproductive age and significantly reduces their quality of life as a result of chronic pelvic pain and infertility. Biologic mechanisms, including persistent inflammation, immune dysfunction, and epigenetic modifications, have been proposed as the pathogenesis of endometriosis. In addition, endometriosis can potentially be associated with an increased risk of pelvic inflammatory disease (PID). Changes in the vaginal microbiota associated with bacterial vaginosis (BV) result in PID or a severe form of abscess formation, tubo-ovarian abscess (TOA). This review aims to summarize the pathophysiology of endometriosis and PID and to discuss whether endometriosis may predispose to PID and vice versa. Methods: Papers published between 2000 and 2022 in the PubMed and Google Scholar databases were included. Results: Available evidence supports that women with endometriosis are at increased risk of comorbid PID and vice versa, supporting that endometriosis and PID are likely to coexist. There is a bidirectional relationship between endometriosis and PID that shares a similar pathophysiology, which includes the distorted anatomy favorable to bacteria proliferation, hemorrhage from endometriotic lesions, alterations to the reproductive tract microbiome, and impaired immune response modulated by aberrant epigenetic processes. However, whether endometriosis predisposes to PID or vice versa has not been identified. Conclusions: This review summarizes our current understanding of the pathogenesis of endometriosis and PID and discusses the similarities between them. Full article
(This article belongs to the Special Issue Diagnostics and Management of Endometriosis)
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