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Diabetology
Special Issues
Nutrition, Lifestyles, and Metabolomics in Diabetes
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Nutrition, Lifestyles, and Metabolomics in Diabetes

A special issue of Diabetology (ISSN 2673-4540).

Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 2141

Special Issue Editor

Dr. Jean Philippe Drouin-Chartier

E-Mail Website
Guest Editor
1. Faculty of Pharmacy, Laval University, Québec, QC, Canada
2. Health and Society Research Center, Laval University, Québec, QC, Canada
Interests: nutrition; medication; metabolomics; cardiometabolic health; cardiovascular health

Special Issue Information

Dear Colleagues,

Type 2 diabetes (T2D) affects >400 million adults worldwide. Diet and lifestyle undisputedly play a major role in its prevention. While there is a substantial body of evidence supporting the beneficial relationship between healthy diet or lifestyle and diabetes prevention, the underlying mechanisms remain unclear in most cases. The integration of metabolomics into nutritional and lifestyle studies may provide valuable information on the biochemical pathways underlying the relationship between diet, lifestyle, and diabetes prevention. The use of metabolomics also has great discovery potential with regard to dietary and lifestyle prevention of diabetes complications such as cardiovascular diseases. We are therefore pleased to invite you to submit your article to the Special Issue “Nutrition, Lifestyles, and Metabolomics in Diabetes” in Diabetology. This Special Issue aims to publish latest findings to advance our understanding on the interplay between diet, lifestyle, metabolomics, and type 2 diabetes prevention and management. Articles than integrate metabolomics into large cohort studies or clinical trials are particularly welcome. We would also be pleased to consider narrative and systematic reviews, as well as meta-analyses of recent studies.

We look forward to receiving your contributions

Dr. Jean Philippe Drouin-Chartier
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diabetology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • lifestyle
  • pharmacology
  • metabolomics
  • diabetes
  • cardiometabolic disease
  • cardiovascular disease

Published Papers (1 paper)

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Research

22 pages, 4377 KiB  
Article
Augmentation and Evaluation of an Olive Oil Based Polyherbal Combination against Diabetic Cardiomyopathy in Experimental Model of Rodents
by Arshiya Shamim, Hefazat H. Siddiqui, Tarique Mahmood, Tanveer A. Wani, Seema Zargar, Mohammad Haris Siddiqui, Alvina Farooqui, Farogh Ahsan, Mohammad Shariq, Saba Parveen, Muhammad Wahajuddin, Pranay Wal and Akash Ved
Diabetology 2022, 3(4), 561-582; https://doi.org/10.3390/diabetology3040043 - 02 Nov 2022
Viewed by 1754
Abstract
Diabetes mellitus is a metabolic disorder that is prima facie a cause for numerous macro and micro vascular complications. A common macroscopic complication associated with diabetes is cardiomyopathy. Cardiomyopathy refers to diseases of the heart muscle, where the heart muscle becomes enlarged, thick, [...] Read more.
Diabetes mellitus is a metabolic disorder that is prima facie a cause for numerous macro and micro vascular complications. A common macroscopic complication associated with diabetes is cardiomyopathy. Cardiomyopathy refers to diseases of the heart muscle, where the heart muscle becomes enlarged, thick, or rigid. As cardiomyopathy worsens, the heart becomes weaker and is unable to conduct the right amount of blood through the body and maintain a normal electrical rhythm. This can lead to heart failure or arrhythmias. Chronic diabetes is one of the instigating factors behind the etiology of this cardiac complication. Type-II diabetes is associated with impaired glucose metabolism that increases the dependence of a diabetic heart on fatty acid oxidation to meet its functional demands, resulting in mitochondrial uncoupling, glucotoxicity, lipotoxicity and initially subclinical cardiac dysfunction that finally gives way to heart failure. The increasing diabetic population with cardiac disorders and the ironically decreasing trend in newer medications to counter this complication leave us at a crossroads for pharmacological management of diabetic cardiomyopathy. Keeping this in view, the present study proclaims a newly developed polyherbal combination (PHC) with three herbs, namely Tinospora cordifolia, Withania somnifera and Boerhavia diffusa based in olive oil and administered in fixed dose (PHC-6 and PHC-10) to screen its cardioprotective potential against a well-established experimental model for diabetic cardiomyopathy. The three herbs mentioned have been known through the traditional literature for their antidiabetic and cardioprotective roles, hence they became the obvious choice. The study follows an experimental model proposed by Reed et al., where the capacity of the β-cell is unobtrusively impeded without totally compromising insulin release, bringing about a moderate disability in glucose resilience. Various sophisticated parameters, namely intraventricular septum thickness of hearts, Western blot of α/β- MHC monoclonal antibody (Ab), cardiac pyruvate dehydrogenase (PDH) activity, medium chain acyl coenzyme A dehydrogenase (MCAD) enzyme, etc. showed promising results where treatment with PHC (PHC-6 and PHC-10) significantly (*** p < 0.001 and **** p < 0.0001) prevented the symptoms of cardiomyopathy in subsequent groups when compared to disease control group. Full article
(This article belongs to the Special Issue Nutrition, Lifestyles, and Metabolomics in Diabetes)
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