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Cosmetics
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Lipid Nanoparticles in Cosmetic Dermal Products
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Lipid Nanoparticles in Cosmetic Dermal Products

A special issue of Cosmetics (ISSN 2079-9284).

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 17180

Special Issue Editors

Prof. Dr. Eliana B. Souto

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Guest Editor
Professor of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, 4099-002 Porto, Portugal
Interests: drug delivery; drug targeting; active pharmaceutical ingredients; volatile compounds; encapsulation
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Patricia Severino

E-Mail Website
Guest Editor
Industrial Biotechnology, Universidade Tiradentes, Aracaju, Brazil
Interests: nanoparticle; drug delivery; biomaterial; cosmetics; biotechnology
Special Issues, Collections and Topics in MDPI journals
Dr. Anđelka Kovačević

E-Mail Website
Guest Editor
Friedrich Schiller Universität Jena, Jena, Germany
Interests: nanoparticles; nanoemulsions; drug delivery; poorly soluble drugs; encapsulation; excipients; drug targeting; dermal bioavailability

Special Issue Information

Dear Colleagues,

Since the introduction of the liposomes (Capture by Dior) onto the cosmetic market in the middle of the 1980s, the cosmetic industry has been waiting for a new efficient cosmetic carrier system.

Lipid nanoparticles with a solid particle matrix derived from o/w emulsions by simply replacing the liquid lipid (oil) with a solid lipid were introduced thirty years ago, and since then, they have been studied intensively for dermal application, both in pharmaceutical and cosmetic uses. These particles exhibit many favorable features for dermal application of cosmetics, i.e., enhancement of chemical stability of actives, film formation (“invisible patch”), occlusive properties, increase in skin hydration, modified release, excellent tolerability, repair and re-enforcement of the natural skin barrier, and protection against UV and IR radiation, among many other benefits. The positive features of lipid nanoparticles have led to the market introduction of a number of cosmetic products.

This Special Issue aims to cover different aspects of lipid nanoparticles and will include papers describing the design, preparation, and characterization of these carrier systems, recent advances, and technological challenges alongside examples of several cosmetic actives and cosmetic products on the market.

Prof. Dr. Eliana B. Souto
Prof. Dr. Patricia Severino
Dr. Anđelka Kovačević
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cosmetics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Lipid nanoparticles
  • Dermal application
  • Cosmetics
  • Cosmeceutics
  • Dermocosmetics

Published Papers (3 papers)

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Research

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11 pages, 6600 KiB  
Article
Antifungal Effect of Liposomal α-Bisabolol and When Associated with Fluconazole
by Camila F. Bezerra, José Geraldo de A. Júnior, Rosilaine de L. Honorato, Antonia Thassya L. dos Santos, Josefa Carolaine P. da Silva, Taís G. da Silva, Thiago S. de Freitas, Thiago Adler T. Vieira, Maria Clara F. Bezerra, Débora Lima Sales, João Pedro V. Rodrigues, José M. Barbosa Filho, Laisla R. Peixoto, Allyson P. Pinheiro, Henrique D. M. Coutinho, Maria Flaviana B. Morais-Braga and Teresinha G. da Silva
Cosmetics 2021, 8(2), 28; https://doi.org/10.3390/cosmetics8020028 - 02 Apr 2021
Cited by 6 | Viewed by 4353
Abstract
Fungal pathologies caused by the genus Candida have increased in recent years due to the involvement of immunosuppressed people and the advance of resistance mechanisms acquired by these microorganisms. Liposomes are nanovesicles with lipid bilayers in which they store compounds. α-Bisabolol is a [...] Read more.
Fungal pathologies caused by the genus Candida have increased in recent years due to the involvement of immunosuppressed people and the advance of resistance mechanisms acquired by these microorganisms. Liposomes are nanovesicles with lipid bilayers in which they store compounds. α-Bisabolol is a sesquiterpene with proven biological activities, and in this work it was tested alone in liposomes and in association with Fluconazole in vitro to evaluate the antifungal potential, Fluconazole optimization, and virulence inhibitory effect in vitro. Antifungal assays were performed against standard strains of Candida albicans, Candida tropicalis, and Candida krusei by microdilution to identify the IC50 values and to obtain the cell viability. The Minimum Fungicidal Concentration (MFC) was performed by subculturing on the solid medium, and at their subinhibitory concentration (Matrix Concentration (MC): 16,384 µg/mL) (MC/16), the compounds, both isolated and liposomal, were associated with fluconazole in order to verify the inhibitory effect of this junction. Tests to ascertain changes in morphology were performed in microculture chambers according to MC concentrations. Liposomes were characterized from the vesicle size, polydispersity index, average Zeta potential, and scanning electron microscopy. The IC50 value of the liposomal bisabolol associated with fluconazole (FCZ) was 2.5 µg/mL against all strains tested, revealing a potentiating effect. Liposomal bisabolol was able to potentiate the effect of fluconazole against the CA and CT strains by reducing its concentration and completely inhibiting fungal growth. α-Bisabolol in liposomal form inhibited the morphological transition in all strains tested at a concentration of MC/8. The liposomes were homogeneous, with vesicles with diameters of 203.8 nm for the liposomal bisabolol and a surface charge potential of −34.2 mV, conferring stability to the nanosystem. Through scanning microscopy, the spherical shapes of the vesicles were observed. Full article
(This article belongs to the Special Issue Lipid Nanoparticles in Cosmetic Dermal Products)
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Review

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33 pages, 765 KiB  
Review
Aeroterrestrial and Extremophilic Microalgae as Promising Sources for Lipids and Lipid Nanoparticles in Dermal Cosmetics
by Maya Stoyneva-Gärtner, Blagoy Uzunov and Georg Gärtner
Cosmetics 2022, 9(1), 11; https://doi.org/10.3390/cosmetics9010011 - 17 Jan 2022
Cited by 2 | Viewed by 4287
Abstract
Microscopic prokaryotic and eukaryotic algae (microalgae), which can be effectively grown in mass cultures, are gaining increasing interest in cosmetics. Up to now, the main attention was on aquatic algae, while species from aeroterrestrial and extreme environments remained underestimated. In these habitats, algae [...] Read more.
Microscopic prokaryotic and eukaryotic algae (microalgae), which can be effectively grown in mass cultures, are gaining increasing interest in cosmetics. Up to now, the main attention was on aquatic algae, while species from aeroterrestrial and extreme environments remained underestimated. In these habitats, algae accumulate high amounts of some chemical substances or develop specific compounds, which cause them to thrive in inimical conditions. Among such biologically active molecules is a large family of lipids, which are significant constituents in living organisms and valuable ingredients in cosmetic formulations. Therefore, natural sources of lipids are increasingly in demand in the modern cosmetic industry and its innovative technologies. Among novelties in skin care products is the use of lipid nanoparticles as carriers of dermatologically active ingredients, which enhance their penetration and release in the skin strata. This review is an attempt to comprehensively cover the available literature on the high-value lipids from microalgae, which inhabit aeroterrestrial and extreme habitats (AEM). Data on different compounds of 87 species, subspecies and varieties from 53 genera (represented by more than 141 strains) from five phyla are provided and, despite some gaps in the current knowledge, demonstrate the promising potential of AEM as sources of valuable lipids for novel skin care products. Full article
(This article belongs to the Special Issue Lipid Nanoparticles in Cosmetic Dermal Products)
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43 pages, 1792 KiB  
Review
Design, Preparation, and Characterization of Effective Dermal and Transdermal Lipid Nanoparticles: A Review
by Dima Khater, Hamdi Nsairat, Fadwa Odeh, Mais Saleh, Areej Jaber, Walhan Alshaer, Abeer Al Bawab and Mohammad S. Mubarak
Cosmetics 2021, 8(2), 39; https://doi.org/10.3390/cosmetics8020039 - 18 May 2021
Cited by 46 | Viewed by 7376
Abstract
Limited permeability through the stratum corneum (SC) is a major obstacle for numerous skin care products. One promising approach is to use lipid nanoparticles as they not only facilitate penetration across skin but also avoid the drawbacks of conventional skin formulations. This review [...] Read more.
Limited permeability through the stratum corneum (SC) is a major obstacle for numerous skin care products. One promising approach is to use lipid nanoparticles as they not only facilitate penetration across skin but also avoid the drawbacks of conventional skin formulations. This review focuses on solid lipid nanoparticles (SLNs), nanostructured lipid nanocarriers (NLCs), and nanoemulsions (NEs) developed for topical and transdermal delivery of active compounds. A special emphasis in this review is placed on composition, preparation, modifications, structure and characterization, mechanism of penetration, and recent application of these nanoparticles. The presented data demonstrate the potential of these nanoparticles for dermal and transdermal delivery. Full article
(This article belongs to the Special Issue Lipid Nanoparticles in Cosmetic Dermal Products)
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