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Nanofabricated Surfaces for Biomedical Applications
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Nanofabricated Surfaces for Biomedical Applications

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: closed (31 May 2020) | Viewed by 16062

Special Issue Editor

Prof. Dr. Jiunn-Der Liao

E-Mail Website
Guest Editor
Department of Materials Science and Engineering, National Cheng Kung University, Tainan, Taiwan
Interests: nanofabricated surfaces; mechanics of biomaterials; plasma medicine; cell-surface interactions; micro-contact imprinting; plasma generation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A man-made nanostructures on a surface can be nanofabricated via top-down, bottom-up, combination, or template-assisted route, which can bring novel physical and/or chemical properties for the coating. For example, a noble-metal-coated substrate with a particular nanostructured surface can be integrated into a measurement system, e.g., as a biosensor component for highly-sensitive detection under a trace amount of target molecule, or for highly selective distinction among target molecules in a complex solution. In particular, for recent years, nanofabricated coatings with surface-enhanced Raman scattering properties have created a great deal of potential for the detection of Raman-active species, ranging from single molecules to biomolecules or bio-organism. For this Special Issue, a nanostructured coating produced through a top-down, bottom-up, combination, or template-assisted route is the main topic. A bottom-up method using, e.g., nanoparticles (NPs) or graphene techniques, is also of interest. In addition, the as-prepared coatings are preferably directed to biomedical applications.

Prof. Dr. Jiunn-Der Liao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanostructure
  • nanofabrication
  • coating
  • biomedical application

Published Papers (5 papers)

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Research

12 pages, 2319 KiB  
Article
Surface Imprinted Layer of Cypermethrin upon Au Nanoparticle as a Specific and Selective Coating for the Detection of Template Pesticide Molecules
by Jaya Sitjar, Ying-Chen Hou, Jiunn-Der Liao, Han Lee, Hong-Zheng Xu, Wei-En Fu and Guo Dung Chen
Coatings 2020, 10(8), 751; https://doi.org/10.3390/coatings10080751 - 01 Aug 2020
Cited by 8 | Viewed by 2832
Abstract
The detection of specific pesticides on food products is essential as these substances pose health risks due to their toxicity. The use of surface-enhanced Raman spectroscopy (SERS) takes advantage of the straightforward technique to obtain fingerprint spectra of target analytes. In this study, [...] Read more.
The detection of specific pesticides on food products is essential as these substances pose health risks due to their toxicity. The use of surface-enhanced Raman spectroscopy (SERS) takes advantage of the straightforward technique to obtain fingerprint spectra of target analytes. In this study, SERS-active substrates are made using Au nanoparticles (NPs) coated with a layer of polymer and followed by imprinting with a pesticide–Cypermethrin, as a molecularly imprinted polymer (MIP). Cypermethrin was eventually removed and formed as template cavities, then denoted as Au NP/MIP, to capture the analogous molecules. The captured molecules situated in-between the areas of high electromagnetic field formed by plasmonic Au NPs result in an effect of SERS. The formation of Au NP/MIP was, respectively, studied through morphological analysis using transmission electron microscopy (TEM) and compositional analysis using X-ray photoelectron spectroscopy (XPS). Two relatively similar pesticides, Cypermethrin and Permethrin, were used as analytes. The results showed that Au NP/MIP was competent to detect both similar molecules despite the imprint being made only by Cypermethrin. Nevertheless, Au NP/MIP has a limited number of imprinted cavities that result in sensing only low concentrations of a pesticide solution. Au NP/MIP is thus a specific design for detecting analogous molecules similar to its template structure. Full article
(This article belongs to the Special Issue Nanofabricated Surfaces for Biomedical Applications)
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11 pages, 5952 KiB  
Article
Synthesis of High-Performance Photonic Crystal Film for SERS Applications via Drop-Coating Method
by Ming-Xue Wei, Chao-Hui Liu, Han Lee, Bo-Wei Lee, Chun-Han Hsu, Hong-Ping Lin and Yu-Chun Wu
Coatings 2020, 10(7), 679; https://doi.org/10.3390/coatings10070679 - 15 Jul 2020
Cited by 8 | Viewed by 3225
Abstract
Silica nanospheres with a well-controlled particle size were prepared via a nucleation-to-growth synthesis process. A facile method is proposed for improving the self-assembly behavior of silica colloidal particles in droplet coatings by the simple controlling of the drying temperature. It is shown that [...] Read more.
Silica nanospheres with a well-controlled particle size were prepared via a nucleation-to-growth synthesis process. A facile method is proposed for improving the self-assembly behavior of silica colloidal particles in droplet coatings by the simple controlling of the drying temperature. It is shown that a periodically arranged, opal-structured, photonic crystal film with a large area of approximately 4.0 cm2 can be prepared, even when the particle size is up to 840 nm. When the band gap of the silica photonic crystals falls in the visible-light region, the crystals exhibit distinct structural colors. Moreover, the wavelength of the reflected light increases with an increasing particle size of silica. When the photonic band gap overlaps the wavelength of the laser source, the overall Raman spectrum intensity is significantly enhanced. Accordingly, the proposed nucleation-to-growth process and drop-coating method provides a cheap and simple approach for the manufacture of uniform sized silica and surface-enhanced Raman scattering substrates, respectively. Full article
(This article belongs to the Special Issue Nanofabricated Surfaces for Biomedical Applications)
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16 pages, 3661 KiB  
Article
Leaf Extract of Dillenia indica as a Source of Selenium Nanoparticles with Larvicidal and Antimicrobial Potential toward Vector Mosquitoes and Pathogenic Microbes
by Meenambigai Krishnan, Kokila Ranganathan, Premkumar Maadhu, Pazhanivel Thangavelu, Sivashanmugan Kundan and Nareshkumar Arjunan
Coatings 2020, 10(7), 626; https://doi.org/10.3390/coatings10070626 - 30 Jun 2020
Cited by 25 | Viewed by 3374
Abstract
Chikungunya, dengue, Zika, malaria, Japanese encephalitis, filariasis, West Nile, etc. are mosquito transmitted diseases that have killed millions of people worldwide, and millions of people are at risk of these diseases. Control of the mosquitoes, such as Aedes aegypti and Culex quinquefasciatus, is [...] Read more.
Chikungunya, dengue, Zika, malaria, Japanese encephalitis, filariasis, West Nile, etc. are mosquito transmitted diseases that have killed millions of people worldwide, and millions of people are at risk of these diseases. Control of the mosquitoes, such as Aedes aegypti and Culex quinquefasciatus, is challenging due to their development of resistance to synthetic insecticides. The habitats of the young mosquitoes are also the habitats for foodborne pathogens like Staphylococcus aureus (MTCC96) and Serratia marcescens (MTCC4822). The present study was aimed at synthesizing eco-friendly green nanoparticles using Dillenia indica leaf broth and analyzing its efficacy in controlling the vector mosquitoes A. aegypti and C. quinquefasciatus, as well as the microbial pathogens St. aureus and Se. marcescens. The formation of selenium nanoparticles (SeNps) was confirmed using UV-Vis spectroscopy (absorption peak at 383.00 nm), Fourier transform infrared radiation (FTIR spectrum peaks at 3177, 2114, 1614, 1502, 1340, 1097, 901, 705, and 508 cm−1), X-ray diffraction (diffraction peaks at 23.3 (100), 29.6 (101), 43.5 (012), and 50.05 (201)), and scanning electron microscopy (oval shaped). The size of the nanoparticles and their stability were analyzed using dynamic light scattering (Z-Average value of 248.0 nm) and zeta potential (−13.2 mV). The SeNps disorganized the epithelial layers and have broken the peritrophic membrane. Histopathological changes were also observed in the midgut and caeca regions of the SeNPs treated A. aegypti and C. quinquefasciatus larvae. The SeNps were also active on both the bacterial species showing strong inhibitory zones. The present results will explain the ability of SeNps in controlling the mosquitoes as well as the bacteria and will contribute to the development of multi potent eco-friendly compounds. Full article
(This article belongs to the Special Issue Nanofabricated Surfaces for Biomedical Applications)
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14 pages, 3456 KiB  
Article
Mutated Human P-Selectin Glycoprotein Ligand-1 and Viral Protein-1 of Enterovirus 71 Interactions on Au Nanoplasmonic Substrate for Specific Recognition by Surface-Enhanced Raman Spectroscopy
by Kundan Sivashanmugan, Han Lee, Jiunn-Der Liao, Chen-Chu Wang, Chen-Hsueh Lin, Yuh-Shyong Yang and Jaya Sitjar
Coatings 2020, 10(4), 403; https://doi.org/10.3390/coatings10040403 - 19 Apr 2020
Cited by 1 | Viewed by 3037
Abstract
Protein tyrosine sulfation is a common post-translational modification that stimulates intercellular or extracellular protein-protein interactions and is responsible for various important biological processes, including coagulation, inflammation, and virus infections. Recently, human P-selectin glycoprotein ligand-1 (PSGL-1) has been shown to serve as a functional [...] Read more.
Protein tyrosine sulfation is a common post-translational modification that stimulates intercellular or extracellular protein-protein interactions and is responsible for various important biological processes, including coagulation, inflammation, and virus infections. Recently, human P-selectin glycoprotein ligand-1 (PSGL-1) has been shown to serve as a functional receptor for enterovirus 71 (EV71). It has been proposed that the capsid viral protein VP1 of EV71 is directly involved in this specific interaction with sulfated or mutated PSGL-1. Surface-enhanced Raman spectroscopy (SERS) is used to distinguish PSGL-1 and VP1 interactions on an Au nanoporous substrate and identify specific VP1 interaction positions of tyrosine residue sites (46, 48, and 51). The three tyrosine sites in PSGL-1 were replaced by phenylalanine (F), as determined using SERS. A strong phenylalanine SERS signal was obtained in three regions of the mutated protein on the nanoporous substrate. The mutated protein positions at (51F) and (48F, 51F) produced a strong SERS peak at 1599–1666 cm−1, which could be related to a binding with the mutated protein and anti-sulfotyrosine interactions on the nanoporous substrate. A strong SERS effect of the mutated protein and VP1 interactions appeared at (48F), (51F), and (46F, 48F). In these positions, there was less interaction with VP1, as indicated by a strong phenylalanine signal from the mutated protein. Full article
(This article belongs to the Special Issue Nanofabricated Surfaces for Biomedical Applications)
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15 pages, 9184 KiB  
Article
Dielectric Nanoparticles Coated upon Silver Hollow Nanosphere as an Integrated Design to Reinforce SERS Detection of Trace Ampicillin in Milk Solution
by Han Lee, Jia-Wei Yang, Jiunn-Der Liao, Jaya Sitjar, Bernard Haochih Liu, Kundan Sivashanmugan, Wei-En Fu and Guo Dung Chen
Coatings 2020, 10(4), 390; https://doi.org/10.3390/coatings10040390 - 15 Apr 2020
Cited by 8 | Viewed by 3218
Abstract
Surface-enhanced Raman scattering (SERS) technique is competent to trace detection of target species, down to the single molecule level. The detection sensitivity is presumably degraded by the presence of non-specific binding molecules that occupy a SERS-active site (or hot spot) on the substrate [...] Read more.
Surface-enhanced Raman scattering (SERS) technique is competent to trace detection of target species, down to the single molecule level. The detection sensitivity is presumably degraded by the presence of non-specific binding molecules that occupy a SERS-active site (or hot spot) on the substrate surface. In this study, a silver hollow nano-sphere (Ag HNS) with cavity has been particularly designed, followed by depositing dielectric nanoparticles (Di NPs) upon Ag HNS. In the integrated nanostructures, Di NPs/Ag HNS were furthermore confirmed by cutting through the cross sections using the Focused Ion Beam (FIB) technique, which provides the Scanning Electron Microscope (SEM) with Energy-dispersive Spectroscope (EDS) mode for identifying the distribution of Di NPs upon Ag HNS. The results have indicated that Di NPs/Ag HNS exhibits small diameter of cavity, and among Di NPs in this study, Al2O3 with lower dielectric constant provides a much higher SERS enhancement factor (e.g., ~6.2 × 107). In this study, to detect trace amounts (e.g., 0.01 ppm) of Ampicillin in water or milk solution, Al2O3 NPs/Ag HNS was found to be more efficient and less influenced by non-specific binding molecules in milk. A substrate with integrated plasmonic and dielectric components was designed to increase the adsorption of target species and to repulse non-specific binding molecules from SERS-active sites. Full article
(This article belongs to the Special Issue Nanofabricated Surfaces for Biomedical Applications)
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