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Special Issue "Reviews in Pediatric Dermatology"

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Dear Colleagues,

This Special Issue will be a collection of comprehensive, up-to-date reviews from experts in the field on topics of “Pediatric Dermatology” addressing all clinical, experimental, epidemiological, and public health aspects of the broad spectrum of skin diseases in children and adolescents.

This includes the review of clinical, experimental, environmental, behavioral, chemical, and genetic data originating from different sources, such as, for example, clinical trials, laboratory investigations, observational epidemiological studies, public health surveys, and governmental/public registers, and their association to dermatological outcomes such as, for example, skin cancer, allergic contact dermatitis, atopic dermatitis, and other skin diseases. Reviews of methodological aspects related to skin health in children from related fields such as biostatistics, epidemiology, data science, bioinformatics, and mathematics are also welcome.

Prof. Dr. Olaf Gefeller
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

skin diseases
skin health
skin cancer
allergic contact dermatitis
atopic dermatitis
other skin diseases
pediatric dermatology

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Open AccessArticle

The Effect of House Dust Sensitization on Skin Sebum and Moisture in Children with Allergic Respiratory Diseases

and

Children 2023, 10(9), 1483; https://doi.org/10.3390/children10091483 - 30 Aug 2023

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Abstract

This study aimed to investigate the levels of skin moisture and sebum in children with a house dust allergy without skin symptoms. This was a case–control study involving children, aged 0–18 years, who were being followed up for an allergic airway disease in a pediatric allergy clinic. Age, gender, hemogram parameters, and IgE values were evaluated. The skin moisture and sebum percentages of the patients and control group were measured by a non-invasive bioimpedance method using a portable digital skin moisture and sebum measurement device on the cubital fossa. The median value of the skin moisture percentage in the house dust mite allergy-positive patient group was significantly lower than that in the house dust mite allergy-negative patients and the control group (p < 0.001). The house dust mite allergy-positive patient group had the lowest skin sebum content. However, there was no statistical significance among the groups in terms of skin sebum percentage (p = 0.102). In the study, children with a house dust allergy were found to have lower levels of skin moisture and sebum. The regular use of moisturizers for children with a house dust allergy should be kept in mind as an effective solution to protect the skin barrier and reduce skin symptoms. Full article

(This article belongs to the Special Issue Reviews in Pediatric Dermatology)

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Severe Pemphigus Vulgaris Resistant to Conventional Therapies and with Hypersensitivity to Rituximab in a 12-Year-Old Child

Maria Beatrice De Felici Del Giudice

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Children 2023, 10(6), 920; https://doi.org/10.3390/children10060920 - 24 May 2023

Cited by 1 | Viewed by 958

Abstract

Pemphigus vulgaris (PV) is a rare, potentially lethal blistering disease typically occurring in adulthood and characterized by autoantibodies directed against mucocutaneous desmosomal proteins. Clinically, flaccid vesicles, bullae and erosions after breakage are the main clinical features. According to the literature, the incidence of PV is rare in the pediatric population, ranging from 1 to 4% of reported cases. We describe an interesting case of a 12-year-old boy with severe PV that was referred to our university hospital for a mucocutaneous disease resistant to anti-infective therapy. Following the appearance of bullous lesions on the skin, antibody screening for autoimmune diseases showed positivity for PV and corticosteroid therapy was started. In view of the numerous adverse effects, we decided to set up biological therapy with rituximab, which was interrupted due to the onset of an urticarial reaction. Further second-line therapies were therefore attempted, with only a partial response. For this reason, a desensitizing therapy with rituximab was decided, thus allowing a clear improvement in the clinical picture and quality of life of the patient. To the best of our knowledge, this is the first report of a child with severe PV resistant to conventional therapies and with an urticarial reaction to rituximab. This case highlights that despite PV being extremely rare in the pediatric population, this diagnosis should not be entirely discounted. In case of severe clinical manifestations, rituximab represents a valid option in children and desensitization tests should be recommended in the presence of hypersensitivity to this drug. Full article

(This article belongs to the Special Issue Reviews in Pediatric Dermatology)

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Special Issue "Reviews in Pediatric Dermatology"

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