Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
2.0
2.4
Journals
Children
Special Issues
Invasive Bacterial Infections in Children: Epidemiology, Risk Factors, Resistance
share announcement

Invasive Bacterial Infections in Children: Epidemiology, Risk Factors, Resistance

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Infectious Diseases".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1326

Special Issue Editors

Dr. Somya Aggarwal

E-Mail Website
Guest Editor
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Interests: bacterial pathogenesis; enteric viral pathogenesis; host-pathogen interaction; microbiome; vaccine and drug development
Dr. Vikas Kumar Somani

E-Mail Website
Guest Editor
Department of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA
Interests: bacterial pathogenesis; pancreatic cancer; vaccine and drug development

Special Issue Information

Dear Colleagues,

Invasive bacterial infections in children pose a significant health concern worldwide due to their potential to cause severe illness and even death. These infections encompass a range of conditions such as bloodstream infections, meningitis, and pneumonia, which can lead to dire health outcomes, especially in vulnerable populations like infants and immunocompromised children. The impact extends beyond immediate health concerns, affecting cognitive and physical development, and often burdening families with emotional and financial stress. The global prevalence of invasive bacterial infections in children varies across regions and is influenced by factors like healthcare infrastructure, socioeconomic status, and vaccination coverage. Developing countries often experience a higher burden of bacterial infections like Streptococcus pneumoniae, Neisseria meningitidis, and Hib, leading to a disproportionate impact on child mortality and morbidity. Vaccination is a cornerstone, as immunization against pathogens like Streptococcus pneumoniae, Hib, and Neisseria meningitidis can significantly reduce infection rates. Hygiene practices, breastfeeding, and maintaining up-to-date immunization schedules also play crucial roles. In cases of infection, early diagnosis is essential to initiate appropriate antibiotic treatment promptly. However, antibiotic resistance is a growing concern, underscoring the importance of judicious antibiotic use to preserve their effectiveness.

Therefore, by understanding their pathogenesis, epidemiology, and adopting comprehensive prevention and treatment strategies, we can work towards reducing the burden of these infections and ensuring the well-being of children worldwide. This Special Issue of Children on “Invasive Bacterial Infections in Children” will include review articles, original research, and case studies that can contribute and enhance our understanding of:

  • Varied global epidemiological profiles;
  • Mechanisms underpinning virulence and pathogenesis;
  • Illuminating case studies;
  • Innovations in prevention and treatment;
  • Navigating contemporary challenges in managing such cases.

Dr. Somya Aggarwal
Dr. Vikas Kumar Somani
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • invasive bacterial infections
  • bacterial sepsis
  • epidemiology
  • bacterial pathogenesis and virulence
  • vaccine or drug development
  • prevention and treatment
  • antibiotic resistance
  • current challenges

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
14 pages, 252 KiB  
Article
Multidrug-Resistant Bacterial Infections in Pediatric Patients Hospitalized at King Abdulaziz University Hospital, Jeddah, Western Saudi Arabia
by Fajr A. Saeedi, Moustafa A. Hegazi, Hani Alsaedi, Ahmed Hussain Alganmi, Jawahir A. Mokhtar, Eilaf Majdi Metwalli, Hanaa Hamadallah, Ghassan S. Siam, Abdullah Alaqla, Abdullah Alsharabi and Sultan Ahmed Alotaibi
Children 2024, 11(4), 444; https://doi.org/10.3390/children11040444 - 07 Apr 2024
Viewed by 475
Abstract
Multidrug-resistant bacterial infections (MDRIs) constitute a major global threat due to increased patient morbidity/mortality and hospital stay/healthcare costs. A few studies from KSA, including our locality, addressed antimicrobial resistance in pediatric patients. This study was performed to recognize the incidence and clinical/microbiologic features [...] Read more.
Multidrug-resistant bacterial infections (MDRIs) constitute a major global threat due to increased patient morbidity/mortality and hospital stay/healthcare costs. A few studies from KSA, including our locality, addressed antimicrobial resistance in pediatric patients. This study was performed to recognize the incidence and clinical/microbiologic features of MDRIs in hospitalized pediatric patients. A retrospective cross-sectional study included pediatric patients < 18 years, admitted to King Abdulaziz University Hospital, between October 2021 and November 2022, with confirmed positive cultures of bacteria isolated from blood/body fluids. Patients’ medical files provided the required data. MDR organisms (MDROs) were identified in 12.8% of the total cultures. The incidence of MDRIs was relatively high, as it was detected in 42% of patients and in 54.3% of positive bacterial cultures especially among critically ill patients admitted to the NICU and PICU. Pneumonia/ventilator-associated pneumonia was the main type of infection in 37.8% of patients with MDROs. Klebsiella pneumoniae was the most common significantly isolated MDRO in 39.5% of MDR cultures. Interestingly, a low weight for (no need for their as terminology weight for age is standard and well-known) was the only significant risk factor associated with MDROs (p = 0.02). Mortality was significantly higher (p = 0.001) in patients with MDROs (32.4%) than in patients without MDROs (3.9%). Patients who died including 85.7% of patients with MDROs had significantly longer durations of admission, more cultures, and utilized a larger number of antibiotics than the surviving patients (p = 0.02, p = 0.01, p = 0.04, respectively). This study provided a comprehensive update on the seriously alarming problem of MDROs, and its impacts on pediatric patients. The detected findings are crucial and are a helpful guide to decid for implementing effective strategies to mitigate MDROs. Full article
(This article belongs to the Special Issue Invasive Bacterial Infections in Children: Epidemiology, Risk Factors, Resistance)
13 pages, 658 KiB  
Review
The Thousand Faces of Invasive Group A Streptococcal Infections: Update on Epidemiology, Symptoms, and Therapy
by Stefania Mercadante, Andrea Ficari, Lorenza Romani, Maia De Luca, Costanza Tripiciano, Sara Chiurchiù, Francesca Ippolita Calo Carducci, Laura Cursi, Martina Di Giuseppe, Andrzej Krzysztofiak, Stefania Bernardi and Laura Lancella
Children 2024, 11(4), 383; https://doi.org/10.3390/children11040383 - 22 Mar 2024
Viewed by 610
Abstract
Invasive infections caused by Streptococcus pyogfenes (iGAS), commonly known as Group A Streptococcus, represent a significant public health concern due to their potential for rapid progression and life-threatening complications. Epidemiologically, invasive GAS infections exhibit a diverse global distribution, affecting individuals of all ages [...] Read more.
Invasive infections caused by Streptococcus pyogfenes (iGAS), commonly known as Group A Streptococcus, represent a significant public health concern due to their potential for rapid progression and life-threatening complications. Epidemiologically, invasive GAS infections exhibit a diverse global distribution, affecting individuals of all ages with varying predisposing factors. The pathogenesis of invasive GAS involves an array of virulence factors that contribute to tissue invasion, immune evasion, and systemic dissemination. In pediatrics, in the last few years, an increase in iGAS infections has been reported worldwide becoming a challenging disease to diagnose and treat promptly. This review highlights the current knowledge on pathogenesis, clinical presentations, and therapeutic approaches for iGAS in children. Full article
(This article belongs to the Special Issue Invasive Bacterial Infections in Children: Epidemiology, Risk Factors, Resistance)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Invasive bacterial infections in children pose a significant health concern worldwide due to their potential to cause severe illness and even death. These infections encompass a range of conditions such as bloodstream infections, meningitis, and pneumonia, which can lead to dire health outcomes, especially in vulnerable populations like infants and immunocompromised children. In cases of infection, early diagnosis is essential to initiate appropriate antibiotic treatment promptly. However, antibiotic resistance is a growing concern, underscoring the importance of judicious antibiotic use to preserve their effectiveness.<false,>Therefore, by understanding their pathogenesis, epidemiology, and adopting comprehensive prevention and treatment strategies, we can work towards reducing the burden of these infections and ensuring the well-being of children worldwide. This Special Issue of Children on “Invasive Bacterial Infections in Children” will include review articles, original research, and case studies.
Back to TopTop