Chemical and Biosensors Based on Metal-Organic Frames (MOFs)

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Materials for Chemical Sensing".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 6433

Special Issue Editors


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Guest Editor
Institute of Medical Engineering, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710061, China
Interests: cell- and molecule-based biosensors; DNA biosensors; microfluidic chips; molecular diagnostics; micro/nano devices for chemical sensing; electrochemical sensors
Special Issues, Collections and Topics in MDPI journals
Institute of Medical Engineering, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710061, China
Interests: olfactory-based biosensors; taste-based biosnesors; nerve tissue engineering; bioengineered olfactory system; olfactory receptor; bioelectronic nose; odorant detection; multichannel recording
Institute of Medical Engineering, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710061, China
Interests: MOFs; aptamer; PAMAM dendrimer; nanomaterials-based biosensors; polymer composites; electrospinning; cellulose; conductive polymer

Special Issue Information

Dear Colleagues,

Metal–organic frameworks (MOFs) provide unprecedented opportunities for the development of novel biosensors due to their decisive advantages, such as a large surface area, high porosity, tunable structures, and flexibility regarding tailored properties. Sensitive elements could be coupled to MOFs in situ through adding bioactive molecules during the synthesis process of MOFs. In addition, the tunable size and large surface area and channels of various sizes make MOFs ideal platforms for constructing hybrid composite materials that are suitable for use as sensitive elements in chemical and biosensing. The applications of MOFs in chemicals and biosensors have attracted increasing attention, which has led to novel structures and features in MOF-based chemical and biosensors, such as a higher stability, higher sensitivity, higher flexibility, and higher specificity. This Special Issue will provide a forum for the latest research activities in the field of MOF-based chemicals and biosensors, with an emphasis on the relevant synthesis and modification of MOFs and their applications. Both review articles and original research papers are solicited in the following areas, among others:

  • Design and synthesis of MOFs for chemosensors;
  • Design and synthesis of MOFs for biosensors;
  • Electrochemical sensors based on MOFs;
  • Colorimetric sensors based on MOFs;
  • Photoelectrochemical sensors based on MOFs;
  • Fluorescent sensors based on MOFs;
  • Electrochemiluminescence sensors based on MOFs.

Prof. Dr. Chunsheng Wu
Dr. Liping Du
Dr. Wei Chen
Guest Editors

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Published Papers (5 papers)

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Research

15 pages, 5019 KiB  
Article
Bipyridyl Ruthenium-Decorated Ni-MOFs on Carbon Nanotubes for Electrocatalytic Oxidation and Sensing of Glucose
by Yu Zhang, Chang Liu, Rongqiu Yan and Chenghong Lei
Chemosensors 2024, 12(3), 39; https://doi.org/10.3390/chemosensors12030039 - 04 Mar 2024
Viewed by 823
Abstract
Bipyridyl Ruthenium-decorated Ni-MOFs on multi-walled carbon nanotubes (MWCNT-RuBpy@Ni-MOF) were synthesized. In an alkaline solution, the glucose was electrocatalytically oxidized at +0.5 V vs. Ag/AgCl at the composite interface of MWCNT-RuBpy@Ni-MOF on a glassy carbon electrode. The Ni3+/Ni2+ redox couples in [...] Read more.
Bipyridyl Ruthenium-decorated Ni-MOFs on multi-walled carbon nanotubes (MWCNT-RuBpy@Ni-MOF) were synthesized. In an alkaline solution, the glucose was electrocatalytically oxidized at +0.5 V vs. Ag/AgCl at the composite interface of MWCNT-RuBpy@Ni-MOF on a glassy carbon electrode. The Ni3+/Ni2+ redox couples in Ni-MOFs played a key role as the active center for the catalytic oxidation of glucose at the electrode, where both RuBpy and MWCNTs enhanced the current responses to glucose. The resulting enzymeless glucose sensor from MWCNT-RuBpy@Ni-MOF exhibited a wide range of linear responses, high sensitivity and selectivity for the determination of glucose. Full article
(This article belongs to the Special Issue Chemical and Biosensors Based on Metal-Organic Frames (MOFs))
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12 pages, 2049 KiB  
Article
Pyrene-Derived Covalent Organic Framework Films: Advancements in Acid Vapor Detection
by Shaikha S. AlNeyadi, Mohammed T. Alhassani, Ali S. Aleissaee and Ibrahim AlMujaini
Chemosensors 2024, 12(3), 37; https://doi.org/10.3390/chemosensors12030037 - 03 Mar 2024
Viewed by 882
Abstract
The expansion of global industry results in the release of harmful volatile acid vapors into the environment, posing a threat to various lifeforms. Hence, it is crucial to prioritize the development of swift sensing systems capable of monitoring these volatile acid vapors. This [...] Read more.
The expansion of global industry results in the release of harmful volatile acid vapors into the environment, posing a threat to various lifeforms. Hence, it is crucial to prioritize the development of swift sensing systems capable of monitoring these volatile acid vapors. This initiative holds great importance in safeguarding a clean and safe environment. This paper presents the synthesis and characterization of pyrene-based covalent organic frameworks (COFs) that exhibit exceptional crystallinity, thermal stability, and intense fluorescence. Three COFs—PP–COF, PT–COF, and PE–COF—were synthesized, demonstrating large surface areas and robust thermal stability up to 400 °C. The fluorescence properties and intramolecular charge transfer within these COFs were significantly influenced by their Schiff base bonding types and π-stacking degrees between COF layers. Notably, PE-COF emerged as the most fluorescent of the three COFs and exhibited exceptional sensitivity and rapid response as a fluorescent chemosensor for detecting HCl in solution. The reversible protonation of imine bonds in these COFs allowed for the creation of highly sensitive acid vapor sensors, showcasing a shift in spectral absorption while maintaining structural integrity. This study highlights the potential of COFs as reliable and reusable sensors for detecting harmful acid vapors and addressing environmental concerns arising from industrial activities. Full article
(This article belongs to the Special Issue Chemical and Biosensors Based on Metal-Organic Frames (MOFs))
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12 pages, 3959 KiB  
Communication
Preparation and Enhanced Acetone-Sensing Properties of ZIF-8-Derived Co3O4@ZnO Microspheres
by Xiangxiang Fan, Susu Yang, Chun Huang, Yujie Lu and Pan Dai
Chemosensors 2023, 11(7), 376; https://doi.org/10.3390/chemosensors11070376 - 05 Jul 2023
Cited by 3 | Viewed by 927
Abstract
In this work, ZIF-8-derived Co3O4@ZnO microspheres were prepared by a liquid-phase concentration-controlled nucleation strategy. The results of the material characterization showed that Co3O4@ZnO microspheres were obtained, and the surface structure could be controlled with the [...] Read more.
In this work, ZIF-8-derived Co3O4@ZnO microspheres were prepared by a liquid-phase concentration-controlled nucleation strategy. The results of the material characterization showed that Co3O4@ZnO microspheres were obtained, and the surface structure could be controlled with the concentration of the ligand. Compared with pure Co3O4 microspheres, the operating temperature of optimized Co3O4@ZnO microspheres increased by 90 °C after the gas-sensing test. The response to 50 ppm acetone of Co3O4@ZnO microspheres was 4.5 times higher than that of pure Co3O4, and the detection limit reached 0.5 ppm. Meanwhile, Co3O4@ZnO microspheres showed a shorter response-recovery time and better selectivity. The enhanced-sensing mechanism of the ZIF-8-derived Co3O4@ZnO microspheres was also analyzed. Full article
(This article belongs to the Special Issue Chemical and Biosensors Based on Metal-Organic Frames (MOFs))
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11 pages, 1585 KiB  
Communication
Dual-Response Photofunctional Covalent Organic Framework for Acid Detection in Various Solutions
by Wenyue Ma, Zijian Gu, Guocui Pan, Chunjuan Li, Yu Zhu, Zhaoyang Liu, Leijing Liu, Yupeng Guo, Bin Xu and Wenjing Tian
Chemosensors 2023, 11(4), 214; https://doi.org/10.3390/chemosensors11040214 - 30 Mar 2023
Viewed by 1247
Abstract
The detection of acid in different solution environments plays a significant role in chemical, environmental and biological fields. However, reducing the constraints of detecting environment, such as aqueous, organic solvents and mixed phases of aqueous and organic phases, remains a challenge. Herein, by [...] Read more.
The detection of acid in different solution environments plays a significant role in chemical, environmental and biological fields. However, reducing the constraints of detecting environment, such as aqueous, organic solvents and mixed phases of aqueous and organic phases, remains a challenge. Herein, by combining N, N, N′, N′-tetrakis(4-aminophenyl)-1,4-phenylenediamine (TPBD) and terephthalaldehyde (TA) via Shiff-base condensation, we constructed a covalent organic framework (COF) TPBD-TA COF. The COF exhibits color change from red to dark red as well as fluorescence quenching with the increase of acid contents in either aqueous or organic solvents, or a mixture of aqueous and organic solvents, due to the weak donor-acceptor interactions within the COF as well as the weak proton ionization ability of the solutions. Therefore, regardless of the detection environment, TPBD-TA COF can realize color and fluorescence dual-response to acid with the detection limit as low as 0.4 μmol/L and 58 nmol/L, respectively, due to the protonation of the nitrogen atoms on imine bonds of the COF. Full article
(This article belongs to the Special Issue Chemical and Biosensors Based on Metal-Organic Frames (MOFs))
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18 pages, 4489 KiB  
Article
Facile Electrochemical Approach Based on Hydrogen-Bonded MOFs-Derived Tungsten Ethoxide/Polypyrrole-Reduced GO Nanocrystal for ppb Level Ammonium Ions Detection
by Sara Maira Mohd Hizam and Mohamed Shuaib Mohamed Saheed
Chemosensors 2023, 11(3), 201; https://doi.org/10.3390/chemosensors11030201 - 21 Mar 2023
Viewed by 1257
Abstract
Ammonium (NH4+) ions are a primary contaminant in the river and along the waterside near an agricultural area, therefore, necessitating sensitive detection of pollutants before irreversibly damaging environment. Herein, a new approach of metal-organic framework-derived tungsten ethoxide/polypyrrole-reduced graphene oxide (MOFs-W(OCH [...] Read more.
Ammonium (NH4+) ions are a primary contaminant in the river and along the waterside near an agricultural area, therefore, necessitating sensitive detection of pollutants before irreversibly damaging environment. Herein, a new approach of metal-organic framework-derived tungsten ethoxide/polypyrrole-reduced graphene oxide (MOFs-W(OCH2CH3)6/Ppy-rGO) electrochemical sensors are introduced. Through a simple hydrothermal process, Ppy-rGO is linked to tungsten ethoxide as an organic linker. This creates the MOFs-W(OCH2CH3)6/Ppy-rGO nanocrystal through hydrogen bonding. The synergistic combination of tungsten ethoxide and Ppy-rGO provides three-fold advantages: stabilization of Ppy-rGO for extended usage, enabling detection of analytes at ambient temperature, and availability of multiple pathways for effective detection of analytes. This is demonstrated through excellent detection of NH4+ ions over a dynamic concentration range of 0.85 to 3.35 µM with a ppb level detection limit of 0.278 µM (9.74 ppb) and a quantitation limit of 0.843 µM (29.54 ppb). The increment in the concentration of NH4+ ions contributes to the increment in proton (H+) concentration. The increment in proton concentration in the solution will increase the bonding activity and thus increase the conductivity. The cyclic voltammetry curves of all concentrations of NH4+ analytes at the operating potential window between −1.5 and 1.5 V exhibit a quasi-rectangular shape, indicating consistent electronic and ionic transport. The distinctive resistance changes of the MOFs-W(OCH2CH3)6/Ppy-rGO to various NH4+ ion concentrations and ultrasensitive detection provide an extraordinary platform for its application in the agriculture industry. Full article
(This article belongs to the Special Issue Chemical and Biosensors Based on Metal-Organic Frames (MOFs))
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