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Sensors and Analytical Techniques in Biochemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 1566

Special Issue Editors


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Guest Editor
School of Pharmacy, Xuzhou Medical University, Xuzhou, China
Interests: nanobiosensing; colorimetric analysis; nanozyme-based sensors; fluorescence imaging; carbon-based porous materials

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Guest Editor
School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou, China
Interests: nanomaterials; metal–organic frameworks; electrochemical /electrochemiluminescence biosensing

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Guest Editor
Institute of Medical Engineering, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710061, China
Interests: cell- and molecule-based biosensors; DNA biosensors; microfluidic chips; molecular diagnostics; micro/nano devices for chemical sensing; electrochemical sensors
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Special Issue Information

Dear Colleagues,

Nanomaterial-based sensors have attracted large interest in multitudinous interdisciplinary applications because of their simplicity, practicability, low cost, robustness, high sensitivity, and selectivity. To date, various highly sensitive sensing platforms in the fields of disease diagnosis, cell communication, food, and environmental analysis have been developed based on fascinating nanomaterials. However, most of the current sensing technologies still face intrinsic challenges due to the lack of high-quality on-demand nanomaterials, high sensitivity and inexpensive sensing devices, which seriously impedes their practical applications in high-sensitivity, high-selectivity, and high-throughput sensing of the targets in vitro and in vivo. To address these challenges, many innovative sensing technologies have been recently developed, such as smartphone-based colorimetric/fluorescence/electrochemical/chemiluminescence/electrochemiluminescence analysis, and photothermal immunoassay combined with fluorescence and/or other readout modes such as the dual-or multimodal sensing platforms, etc. Therefore, the development of nanomaterial-based sensors represents considerable progress in analytical chemistry and diagnostics.

The objective of this Special Issue is to collect the latest and innovative advances regarding the development of nanomaterial-based sensors. The editors welcome original research, mini-review and review articles, and perspectives with a focus on sensors for biochemical/pharmaceutical/food/environmental analysis. Potential topics include, but are not limited to, the following:

  • The synthesis of novel nanomaterials for sensing;
  • The construction of sensors based on diverse principles;
  • Development of miniaturized sensors;
  • Colorimetric/fluorescence/electrochemical/chemiluminescence/electrochemiluminescence sensors;
  • Smartphone/localized surface plasmon resonance/surface-enhanced Raman scattering-based sensors.

Prof. Dr. Ruilin Liu
Dr. Huiping Sun
Prof. Dr. Chunsheng Wu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterial-based sensors
  • colorimetric/fluorescence nanosensors
  • biochemical analysis
  • smartphone-based nanosensors
  • nanosensing
  • multimodal sensing

Published Papers (1 paper)

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Research

15 pages, 4306 KiB  
Article
Immunosensor with Enhanced Electrochemiluminescence Signal Using Platinum Nanoparticles Confined within Nanochannels for Highly Sensitive Detection of Carcinoembryonic Antigen
by Huihua Zhang, Chaoyan Zhang, Hui Qu and Fengna Xi
Molecules 2023, 28(18), 6559; https://doi.org/10.3390/molecules28186559 - 11 Sep 2023
Cited by 6 | Viewed by 1176
Abstract
Rapid, highly sensitive, and accurate detection of tumor biomarkers in serum is of great significance in cancer screening, early diagnosis, and postoperative monitoring. In this study, an electrochemiluminescence (ECL) immunosensing platform was constructed by enhancing the ECL signal through in situ growth of [...] Read more.
Rapid, highly sensitive, and accurate detection of tumor biomarkers in serum is of great significance in cancer screening, early diagnosis, and postoperative monitoring. In this study, an electrochemiluminescence (ECL) immunosensing platform was constructed by enhancing the ECL signal through in situ growth of platinum nanoparticles (PtNPs) in a nanochannel array, which can achieve highly sensitive detection of the tumor marker carcinoembryonic antigen (CEA). An inexpensive and readily available indium tin oxide (ITO) glass electrode was used as the supporting electrode, and a layer of amino-functionalized vertically ordered mesoporous silica film (NH2-VMSF) was grown on its surface using an electrochemically assisted self-assembly method (EASA). The amino groups within the nanochannels served as anchoring sites for the one-step electrodeposition of PtNPs, taking advantage of the confinement effect of the ultrasmall nanochannels. After the amino groups on the outer surface of NH2-VMSF were derivatized with aldehyde groups, specific recognition antibodies were covalently immobilized followed by blocking nonspecific binding sites to create an immunorecognition interface. The PtNPs, acting as nanocatalysts, catalyzed the generation of reactive oxygen species (ROS) with hydrogen peroxide (H2O2), significantly enhancing the ECL signal of the luminol. The ECL signal exhibited high stability during continuous electrochemical scanning. When the CEA specifically bound to the immunorecognition interface, the resulting immune complexes restricted the diffusion of the ECL emitters and co-reactants towards the electrode, leading to a reduction in the ECL signal. Based on this immune recognition-induced signal-gating effect, the immunosensor enabled ECL detection of CEA with a linear range of 0.1 pg mL−1 to 1000 ng mL−1 with a low limit of detection (LOD, 0.03 pg mL−1). The constructed immunosensor demonstrated excellent selectivity and can achieve CEA detection in serum. Full article
(This article belongs to the Special Issue Sensors and Analytical Techniques in Biochemistry)
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