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Chemistry
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Hybrid Compounds Tailoring at the Nanoscale for Biomedical Applications
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Hybrid Compounds Tailoring at the Nanoscale for Biomedical Applications

A special issue of Chemistry (ISSN 2624-8549). This special issue belongs to the section "Chemistry at the Nanoscale".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 5366

Special Issue Editors

Dr. Giulia Neri

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Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
Interests: engeneering and surface properties characterization of polymeric materials to obtain new nanotheranostic platforms, to employ as sensing, imaging and therapeutic tools; development of hybrid nanosystems based on polymeric materials to design particle and fiber tools for controlled drug release
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Enza Fazio

E-Mail Website
Guest Editor
Department of Mathematical and Computational Sciences, Physics Science and Earth Science, University of Messina, Messina, Italy
Interests: nanomaterials synthesis; electrospun nanofibers; pulsed laser ablation; laser triggered smart nanocomposites; vibrational and electronical spectroscopies (micro-Raman, XPS); morphological techniques (SEM-EDX, DLS); nonlinear optical response (z-scan method)
Special Issues, Collections and Topics in MDPI journals
Dr. Carmelo Corsaro

E-Mail Website
Guest Editor
MIFT Department, Università degli Studi di Messina, Messina, Italy
Interests: NMR spectroscopy; physics of complex systems; aqueous systems; dynamical arrest; protein folding/unfolding; cellulose degradation; metabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

Currently, most of the common diagnostic and therapeutic agents require high doses and often do not efficiently accumulate in the target sites, resulting in side effects. Therefore, the demand for more sharp and sophisticated biomedical tools has grown. Considering the peculiar properties that appear at the nanoscale level, several nanomaterials such as polymers, ceramics, metals, etc. are employed in the biomedicine field. Today, the development of hybrid compounds arising from the combination of materials of different nature, via covalent or non-covalent bonds, represents a new frontier. The combination of functional components plays a crucial role to tune the properties of these new materials, providing also multifunctional nanosystems. Nanohybrid compounds have shown several advantages, such as tunable size, shape, and surface properties, high loading capacity, leading capacity to a specific site, and stimuli-responsive drug release kinetics. These features often lead to improving their biocompatibility and pharmacokinetic profile.

The present Special Issue aims to outline the state-of-the-art regarding the development of hybrid compounds tailoring at the nanoscale, for drug/gene delivery systems, imaging probes, tissue engineering scaffolds, vascular stents, theranostic agents, dental implants, etc. Emphasis will be given to works with a deep characterization of hybrid nanomaterials which allows explaining their peculiar properties for biomedical applications.

You may choose our Joint Special Issue in Molecules.

Dr. Giulia Neri
Dr. Enza Fazio
Dr. Carmelo Corsaro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemistry is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanohybrid compounds
  • functional materials
  • chemical–physical properties
  • nanoscale level
  • biomedicine
  • imaging
  • medical devices
  • theranostic
  • scaffold
  • implants

Published Papers (2 papers)

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Research

11 pages, 2464 KiB  
Article
Hydrothermally Synthesized Hydroxyapatite-Silica Composites with Enhanced Mechanical Properties for Bone Graft Applications
by Atiek Rostika Noviyanti, Juliandri Juliandri, Engela Evy Ernawati, Haryono Haryono, Solihudin Solihudin, Dina Dwiyanti, Azman Ma’amor, Ferli Septi Irwansyah and Sharifuddin Bin Md Zain
Chemistry 2023, 5(3), 1645-1655; https://doi.org/10.3390/chemistry5030113 - 28 Jul 2023
Cited by 1 | Viewed by 1238
Abstract
The demand for synthetic bone grafts has increased in recent years. Hydroxyapatite (HA) is one of the highly suitable candidates as a bone graft material due to its excellent biocompatibility and high osteoconductive properties with low toxicity. HA has disadvantageous mechanical strength showing [...] Read more.
The demand for synthetic bone grafts has increased in recent years. Hydroxyapatite (HA) is one of the highly suitable candidates as a bone graft material due to its excellent biocompatibility and high osteoconductive properties with low toxicity. HA has disadvantageous mechanical strength showing relatively fragile and brittle behavior due to its high hygroscopic properties. This leads to improper mechanical properties for such grafting applications. Therefore, HA should be combined with another material with similar biocompatibility and high hardness, such as SiO2. In this work, HA/SiO2 (HAS) composite material was prepared via a hydrothermal method to obtain the high purities of HA with a particle size of approximately 35 nm and around 50% crystallinity. It was found that the addition of SiO2 stimulated the composite system by forming an orthosilicic acid complex that can reduce the overall solution’s pH, thus contributing to the integrity and stability of the HAS composite. Therefore, higher SiO2 contents in the HAS composite can enhance its mechanical stability when immersed in simulated body fluid (SBF). Our work demonstrated that HAS can highly improve HA material’s hardness and mechanical stability under immersion of SBF. The Vickers test showed that the 0.05 GPa hardness in 10% SiO2 increased to 0.35 GPa hardness with the addition of 20% SiO2. The crystal structures of HAS were analyzed using X-ray diffraction, and the morphology of the HAS composites was observed under electron microscopy. Full article
(This article belongs to the Special Issue Hybrid Compounds Tailoring at the Nanoscale for Biomedical Applications)
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11 pages, 2245 KiB  
Article
Biofabrication of Silver Nanoparticles Using Teucrium Apollinis Extract: Characterization, Stability, and Their Antibacterial Activities
by Wanisa Abdussalam-Mohammed, Laila Mohamed, Mohammed S. Abraheem, Mohmeed M.A Mansour and Akram Mansour Sherif
Chemistry 2023, 5(1), 54-64; https://doi.org/10.3390/chemistry5010005 - 02 Jan 2023
Cited by 9 | Viewed by 3610
Abstract
Medical science has paid a great deal of attention to green synthesis silver nanoparticles (AgNPs) because of their remarkable results with multidrug-resistant bacteria. This study was conducted on the preparation of AgNPs, using the teucrium apollinis extract as a reducing agent and a [...] Read more.
Medical science has paid a great deal of attention to green synthesis silver nanoparticles (AgNPs) because of their remarkable results with multidrug-resistant bacteria. This study was conducted on the preparation of AgNPs, using the teucrium apollinis extract as a reducing agent and a capping ligand. The AgNP produced was stable in room condition up to 10 weeks. The AgNP was characterized using UV-visible absorption spectroscopy (UV-Vis), attenuated Fourier transform infrared (ATR-FTIR), transmission electron microscopy (TEM), and dynamic light scattering (DLS). The study confirms the ability of teucrium apollinis to produce AgNPs with high stability. The influence of pH was studied over a pH range of (2–12) on the stability of synthesized AgNPs. The best value of pH was 7.2, where AgNP showed a good stability with high antibacterial activity against Pseudomonas aeruginosa. AgNP synthesis is confirmed by a strong peak in the UV-Vis due to surface plasmon resonance (SPR) at 379 nm. Based on TEM findings, monodispersed AgNP has a spherical shape with a small size of 16 ± 1.8 nm. In this study, teucrium apollinis extract was used for the first time, which could be a good environmental method for synthesizing AgNP, which offers a possible alternative to chemical AgNPs. Full article
(This article belongs to the Special Issue Hybrid Compounds Tailoring at the Nanoscale for Biomedical Applications)
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