Recent Advances of Apoptosis and Autophagy in Cardiovascular Diseases and Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 65
Special Issue Editors
Interests: autophagy homeostasis, cell death programs; molecular imaging; theranostics; cardiovascular physiology and pathophysiology; cardiomyopathy and heart failure; cardio-oncology
Interests: extracellular vesicles; microRNA; canine translational models; mitral valve prolapse; cardio-oncology
Interests: autophagy machinery; hypertrophic and dilated cardiomyopathy; cell volume regulation; non-canonical autophagy; mitochondria; extracellular vesicles
Special Issue Information
Dear Colleagues,
Apoptosis and autophagy are hallmarks of human disease affecting virtually all major tissue types. Cardiovascular diseases and cancer remain the top two most devastating human disorders in terms of mortality and morbidity, and they are driven by complex mechanisms that may involve similar molecular pathways. This Special Issue will focus on the mechanism of autophagy and apoptosis crosstalk in cardiovascular diseases, in cancer and cancer treatment, and at the intersection of cancer-treatment-induced cardiovascular dysfunction. All of those conditions share common signatures in autophagy dysregulation leading to apoptotic cell death, but the precise underlying molecular mechanisms leading to cell demise/survival and disease pathogenesis remains poorly characterized. There is thus a critical need for interdisciplinary studies from the scientific community to discover novel autophagy mechanisms—the link to precise cell death programs (i.e., apoptosis, necrosis, autosis, ferroptosis, etc.)—and new biomarkers that can lead to the further development of pharmacological strategies suitable for clinical translation. The aim of this Special Issue is to provide state-of-the-art understandings of autophagy and apoptosis at the molecular, cellular, tissue, and organismal levels that underlie cardiovascular disease, cancer, and cancer-treatment-induced cardiotoxicity with the potential to improve human health.
Dr. Howard Chen
Dr. Vicky K. Yang
Dr. Asma Boukhalfa
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- autophagy
- apoptosis
- cardiovascular disease
- cancer
- cardio-oncology
- cardioprotection
- circulating biomarkers
- 3D culture
- animal models
- clinical translation
- drug development
- metabolism
- inflammation
- signaling pathways
