Organelle Contact and Its Physiological Implications
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 May 2024 | Viewed by 275
Special Issue Editors
2.The Network Center for Biomedical Research in Neurodegenerative Diseases, Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), Madrid, Spain
3. Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience Maurice Wohl Clinical Neuroscience, Institute King's College London, 5 Cutcombe Road, London SE5 9RX, UK
Interests: mechanisms of neurodegeneration; mitochondria-associated membranes; autophagy; motor neurone disease
Special Issue Information
Dear Colleagues,
Inter-organelle communication is an emerging and challenging field of study. Dynamic physical and functional associations between different cellular organelles occur at specialized membrane microdomains, known as membrane contact sites (MCSs). These associations regulate crucial physiological processes in eukaryotic cells. Indeed, increasing evidence demonstrates that MSCs represent hotspot signaling domains acting at multiple cellular pathways such as energy and lipid metabolism, ion signaling or proteostasis. Accordingly, impairments in this cross-organelle communication have been associated with multiple pathological conditions, including neurodegeneration, cancer or diabetes.
Contacts between the endoplasmic reticulum and mitochondria are the best-characterized MSCs. Lately, interest has arisen on mapping communication between these and other organelles, such as lysosomes, lysosome-related organelles, peroxisomes, the nucleus or lipid doplets.
This Special Issue will highlight current advances on organelle contacts as key metabolic hubs, focusing on the following fields of study:
- Regulation and physiological implications of inter-organelle communication.
- Links between alterations of organelle contacts and disease.
- Development of methods for visualization and manipulation of inter-organelle communication.
- Description of new molecular players involved in mediating these junctions.
Dr. Patricia Gómez-Suaga
Dr. Estela Area Gomez
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- inter-organelle communication
- membrane contact sites
- organelle dynamics
- mitochondria-associated membranes
- cellular homeostasis
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Lipid droplet-organelle contacts: contribution to emerging lipid droplet functions.
Authors: Miguel Sánchez-Álvarez
Affiliation: Instituto de Investigaciones Biomédicas "Sols-Morreale", Madrid, Spain
Abstract: Contrasting with an initial view of lipid droplets as passive lipid accumulations, these highly dynamic organelles have been revealed as key hubs integrating metabolism with unexpected functions, including proteostasis and cell defence against pathogens. In this review, we provide an update on our current knowledge about their regulated communication with other cell compartments, and how these contacts contribute to those novel biological roles of lipid droplets.
