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Cancers
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Environmental Contaminants and Cancer
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Environmental Contaminants and Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: closed (10 July 2023) | Viewed by 5134

Special Issue Editor

Dr. Muhammad Kibriya

E-Mail Website
Guest Editor
1. Institute for Population and Precision Health (IPPH), Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA
2. Department of Public Health Sciences, Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA
Interests: colorectal carcinoma; microsatellite instability; cytogenetics; molecular genomics; GWAS; copy number change; telomere; methylation; liquid biopsy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Cancer is often associated with environmental exposure to certain carcinogens, which usually exert their effect through genomic alterations. On one hand, the magnitude of the exposure is important; on the other hand, the individual susceptibility and, often, the interaction between the two are important for carcinogenesis. Based on available scientific evidence, mainly from the two major organizations—(a) The International Agency for Research on Cancer (IARC), the cancer agency of the World Health Organization, and (b) the National Toxicology Program (NTP), an interagency program of the US department of Health and Human Services (HHS)— lists of substances anticipated to be human carcinogens have been developed. From the human health perspective (both public health and personalized health/treatment), environmental factors may include the natural or man-made agents, substances, mixtures, or exposures (collectively called “substances”) encountered in daily life—mainly (a) indoor and outdoor air pollution, and (b) soil and drinking water contamination.

Some exposures may be avoidable/minimized, but others may be harder to avoid. Studies addressing the identification of such “substances” and potential biomarkers, the magnitude of exposure, interaction with other biological factors (including gender and genomics) and the actual contribution to the development of human cancer will help better understanding the future possibilities of intervention at the public health or personalized medicine level. 

This Special Issue will highlight the different aspects of such environmental exposure and gene-environmental interaction, covering basic, preclinical and clinical aspects that will advance our understanding of strategies targeting the complexity of cancer.

Dr. Muhammed Kibriya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

19 pages, 1787 KiB  
Article
Predictors of Testicular Cancer Mortality in Brazil: A 20-Year Ecological Study
by Ana Paula de Souza Franco, Eric Renato Lima Figueiredo, Giovana Salomão Melo, Josiel de Souza e Souza, Nelson Veiga Gonçalves, Fabiana de Campos Gomes and João Simão de Melo Neto
Cancers 2023, 15(16), 4149; https://doi.org/10.3390/cancers15164149 - 17 Aug 2023
Cited by 2 | Viewed by 903
Abstract
Testicular cancer is common in young men, and early detection and multimodality treatment can lead to successful outcomes. This study aims to identify sociodemographic and risk factors associated with higher testicular cancer mortality and poorer survival rates, while examining the impact of diagnostic [...] Read more.
Testicular cancer is common in young men, and early detection and multimodality treatment can lead to successful outcomes. This study aims to identify sociodemographic and risk factors associated with higher testicular cancer mortality and poorer survival rates, while examining the impact of diagnostic and treatment procedures on reducing mortality. The retrospective ecological study analyzed mortality data from testicular cancer in Brazil from 2001 to 2020. Sociodemographic variables such as marital status, age, birth period, year of death (cohort), race, and geographic region were assessed. Risk factors included cryptorchidism and pesticide exposure. Data were subjected to statistical analysis, which revealed an increasing trend in mortality after 2011 among persons born after 1976 in the 15–40 age group. Individuals in the South Region, whites, and singles had higher age-standardized mortality rates (ASMRs), while singles had lower survival rates. The Northeast region had a higher survival rate. Fungicides and insecticides increase ASMR in Brazil. Herbicides increase ASMR in the Northeast and Midwest regions and insecticides increase ASMR in the Northeast, Southeast, and Midwest regions. High rates of implementation of diagnostic procedures in the Midwest were not sufficient to reduce ASMR. No treatment procedure was associated with mortality at the national or regional level. Full article
(This article belongs to the Special Issue Environmental Contaminants and Cancer)
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19 pages, 5865 KiB  
Article
Interaction of Arsenic Exposure and Transcriptomic Profile in Basal Cell Carcinoma
by Muhammad G. Kibriya, Farzana Jasmine, Aaron Munoz, Tariqul Islam, Alauddin Ahmed, Lin Tong, Muhammad Rakibuz-Zaman, Mohammad Shahriar, Mohammed Kamal, Christopher R. Shea, Joseph H. Graziano, Maria Argos and Habibul Ahsan
Cancers 2022, 14(22), 5598; https://doi.org/10.3390/cancers14225598 - 15 Nov 2022
Cited by 1 | Viewed by 1596
Abstract
Exposure to inorganic arsenic (As) is recognized as risk factor for basal cell carcinoma (BCC). We have followed-up 7000 adults for 6 years who were exposed to As and had manifest As skin toxicity. Of them, 1.7% developed BCC (males = 2.2%, females [...] Read more.
Exposure to inorganic arsenic (As) is recognized as risk factor for basal cell carcinoma (BCC). We have followed-up 7000 adults for 6 years who were exposed to As and had manifest As skin toxicity. Of them, 1.7% developed BCC (males = 2.2%, females = 1.3%). In this study, we compared transcriptome-wide RNA sequencing data from the very first 26 BCC cases and healthy skin tissue from independent 16 individuals. Genes in “ cell carcinoma pathway”, “Hedgehog signaling pathway”, and “Notch signaling pathway” were overexpressed in BCC, confirming the findings from earlier studies in BCC in other populations known to be exposed to As. However, we found that the overexpression of these known pathways was less pronounced in patients with high As exposure (urinary As creatinine ratio (UACR) > 192 µg/gm creatinine) than patients with low UACR. We also found that high UACR was associated with impaired DNA replication pathway, cellular response to different DNA damage repair mechanisms, and immune response. Transcriptomic data were not strongly suggestive of great potential for immune checkpoint inhibitors; however, it suggested lower chance of platinum drug resistance in BCC patients with high UACR compared high platinum drug resistance potential in patients with lower UACR. Full article
(This article belongs to the Special Issue Environmental Contaminants and Cancer)
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16 pages, 1847 KiB  
Article
Environmental Contaminants Modulate Breast Cancer Development and Outcome in TP53 p.R337H Carriers and Noncarriers
by Viviane K. Q. Gerber, Mariana M. Paraizo, Humberto C. Ibañez, José C. Casali-da-Rocha, Emilia M. Pinto, Diancarlos P. Andrade, Marilea V. C. Ibañez, Heloisa Komechen, Mirna M. O. Figueiredo, Gislaine Custódio, Carmem M. C. M. Fiori, José H. G. Balbinotti, Jeanine M. Nardin, Thais A. Almeida, Olair O. Beltrame, Paula A. Yamada, Gabriel S. de Fraga, Lucas L. de Brito, Jamylle Martins, Viviane S. Melanda, Otavio A. B. Licht, Victoria Z. Teixeira, Sandy K. S. Pinho, Silvia Bottini, Enzo Lalli, Gerard P. Zambetti and Bonald C. Figueiredoadd Show full author list remove Hide full author list
Cancers 2022, 14(12), 3014; https://doi.org/10.3390/cancers14123014 - 19 Jun 2022
Cited by 1 | Viewed by 1958
Abstract
Two major concerns associated with cancer development in Paraná state, South Brazil, are environmental pollution and the germline TP53 p.R337H variant found in 0.27–0.30% of the population. We assessed breast cancer (BC) risk in rural (C1 and C2) and industrialized (C3) subregions, previously [...] Read more.
Two major concerns associated with cancer development in Paraná state, South Brazil, are environmental pollution and the germline TP53 p.R337H variant found in 0.27–0.30% of the population. We assessed breast cancer (BC) risk in rural (C1 and C2) and industrialized (C3) subregions, previously classified by geochemistry, agricultural productivity, and population density. C2 presents lower organochloride levels in rivers and lower agricultural outputs than C1, and lower levels of chlorine anions in rivers and lower industrial activities than C3. TP53 p.R337H status was assessed in 4658 women aged >30 years from C1, C2, and C3, subsequent to a genetic screening (Group 1, longitudinal study). BC risk in this group was 4.58 times higher among TP53 p.R337H carriers. BC prevalence and risk were significantly lower in C2 compared to that in C3. Mortality rate and risk associated with BC in women aged >30 years (n = 8181 deceased women; Group 2) were also lower in C2 than those in C3 and C1. These results suggest that environmental factors modulate BC risk and outcome in carriers and noncarriers. Full article
(This article belongs to the Special Issue Environmental Contaminants and Cancer)
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