Lung Cancer Screening and Smoking Cessation Efforts

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3753

Special Issue Editors


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Guest Editor
Department of Oncology and Hemato-Oncology, University in Milan, Milan, Italy
Interests: cancer screening; smoking; cancer survivorship; smoking reduction

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Guest Editor
European Institute of Oncology, Milan, Italy
Interests: cancer patients psychology; depressive symptoms; breast cancer patients

Special Issue Information

Dear Colleagues, 

Tobacco smoking is considered the foremost cause of premature death and dramatically affects clinical outcomes and quality of life in cancer patients. However, several studies have highlighted the persistence of smoking after a cancer diagnosis, despite the consequences on treatments’ efficacy and long-term survival rate. Likewise, lung cancer screening for high-risk individuals, when available in the local health system, does not reach all target groups; furthermore, cancer screening is not always a “teachable moment”. 

Thus, this Special Issue aims to provide a more comprehensive theoretical framework and evidence-based knowledge about psychological, cognitive, social, relational, and environmental determinants of tobacco smoking behavior in high-risk individuals (subjects enrolled in a screening program for early detection of lung cancer, or cancer patients) and their interaction with physical variables related to nicotine addiction, and with disease onset and progression. 

We welcome papers investigating the interrelation among determinants (e.g., psycho-social, environmental, and biological) affecting the risk of low adherence to smoking cessation programs, to cancer screening, and affecting the risk of lung cancer development. Papers studying innovative programs to affect the aforementioned risks are also accepted.

Dr. Marianna Masiero
Dr. Ketti Mazzocco
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer screening
  • smoking-cessation interventions
  • survivorship
  • decision making
  • cognitive bias in tobacco behaviors
  • personality
  • emotion regulation
  • predictive risk model
  • immune response
  • e-cigarette

Published Papers (2 papers)

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Research

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18 pages, 1805 KiB  
Article
Cost-Effectiveness Analysis of Risk Factor-Based Lung Cancer Screening Program by Low-Dose Computer Tomography in Current Smokers in China
by Tiantian Zhang, Xudong Chen, Caichen Li, Xiaoqin Wen, Tengfei Lin, Jiaxing Huang, Jianxing He, Nanshan Zhong, Jie Jiang and Wenhua Liang
Cancers 2023, 15(18), 4445; https://doi.org/10.3390/cancers15184445 - 6 Sep 2023
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Abstract
Although the effectiveness of lung cancer screening by low-dose computed tomography (LDCT) could be shown in China, there could be variation in the evidence concerning the economic impact. Our study explores the cost-effectiveness of lung cancer screening and optimizes the best definition of [...] Read more.
Although the effectiveness of lung cancer screening by low-dose computed tomography (LDCT) could be shown in China, there could be variation in the evidence concerning the economic impact. Our study explores the cost-effectiveness of lung cancer screening and optimizes the best definition of a high-risk population. A Markov model consisting of the natural history and post-diagnosis states was constructed to estimate the costs and quality-adjusted life years (QALYs) of LDCT screening compared with no screening. A total of 36 distinct risk factor-based screening strategies were assessed by incorporating starting ages of 40, 45, 50, 55, 60 and 65 years, stopping ages of 69, 74 and 79 years as well as smoking eligibility criteria. Screening data came from community-based mass screening with LDCT for lung cancer in Guangzhou. Compared with no screening, all screening scenarios led to incremental costs and QALYs. When the willingness-to-pay (WTP) threshold was USD37,653, three times the gross domestic product (GDP) per capita in China, six of nine strategies on the efficiency frontier may be cost-effective. Annual screening between 55 and 79 years of age for those who smoked more than 20 pack-years, which yielded an incremental cost-effectiveness ratio (ICER) of USD35,000.00 per QALY gained, was considered optimal. In sensitivity analyses, the result was stable in most cases. The trends of the results are roughly the same in scenario analyses. According to the WTP threshold of different regions, the optimal screening strategies were annual screening for those who smoked more than 20 pack-years, between 50 and 79 years of age in Zhejiang province, 55–79 years in Guangdong province and 65–74 years in Yunnan province. However, annual screening was unlikely to be cost-effective in Heilongjiang province under our modelling assumptions, indicating that tailored screening policies should be made regionally according to the local epidemiological and economic situation. Full article
(This article belongs to the Special Issue Lung Cancer Screening and Smoking Cessation Efforts)
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Review

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18 pages, 1197 KiB  
Review
Clinical Scores, Biomarkers and IT Tools in Lung Cancer Screening—Can an Integrated Approach Overcome Current Challenges?
by Wieland Voigt, Helmut Prosch and Mario Silva
Cancers 2023, 15(4), 1218; https://doi.org/10.3390/cancers15041218 - 14 Feb 2023
Cited by 1 | Viewed by 2074
Abstract
As most lung cancer (LC) cases are still detected at advanced and incurable stages, there are increasing efforts to foster detection at earlier stages by low dose computed tomography (LDCT) based LC screening. In this scoping review, we describe current advances in candidate [...] Read more.
As most lung cancer (LC) cases are still detected at advanced and incurable stages, there are increasing efforts to foster detection at earlier stages by low dose computed tomography (LDCT) based LC screening. In this scoping review, we describe current advances in candidate selection for screening (selection phase), technical aspects (screening), and probability evaluation of malignancy of CT-detected pulmonary nodules (PN management). Literature was non-systematically assessed and reviewed for suitability by the authors. For the selection phase, we describe current eligibility criteria for screening, along with their limitations and potential refinements through advanced clinical scores and biomarker assessments. For LC screening, we discuss how the accuracy of computerized tomography (CT) scan reading might be augmented by IT tools, helping radiologists to cope with increasing workloads. For PN management, we evaluate the precision of follow-up scans by semi-automatic volume measurements of CT-detected PN. Moreover, we present an integrative approach to evaluate the probability of PN malignancy to enable safe decisions on further management. As a clear limitation, additional validation studies are required for most innovative diagnostic approaches presented in this article, but the integration of clinical risk models, current imaging techniques, and advancing biomarker research has the potential to improve the LC screening performance generally. Full article
(This article belongs to the Special Issue Lung Cancer Screening and Smoking Cessation Efforts)
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