The Neuroscience behind Addiction
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Nutritional Neuroscience".
Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 402
Special Issue Editors
Interests: neural mechanisms underlying addiction; smoking cessation
Special Issue Information
Dear Colleagues,
Substance use disorders (SUDs), characterized by compulsive, reckless drug seeking and repeated relapse, are chronic and relapsing brain disorders that have substantial negative impact. Given the persistence of the addiction phenotype at both behavioral abnormality and transcriptional levels, current accumulated studies have elucidated that epigenetic and transcriptional adaptations in brain reward and non-reward circuits are involved in these disorders. In this Special Issue, we highlight epigenetic modulations, including the level of histone acetylation and histone methylation as well as alterations to DNA methylation/hydroxymethylation patterns and noncoding RNA expression and synaptic plasticity throughout brain reward regions in addiction. Causal links between these epigenetic modifications and changes in addiction-related behavior were revealed by manipulating epigenetic enzymes in specific brain regions.
It is my best wish that this Special Issue will further our understanding of the mechanisms underlying addiction, and eventually drive translational studies to develop more effective treatments for addiction and the relief of relative behavioral abnormalities.
Dr. Yanhui Liao
Dr. Jianhua Chen
Guest Editors
Manuscript Submission Information
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Keywords
- addiction
- substance use disorders
- chromatin
- genetic and epigenetic regulatory
- transcription factors
- post-translational modifications
- DNA methylation
- noncoding RNAs
- synaptic plasticity
