DNA Biosensors for Diagnostics

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (31 December 2023)

Special Issue Editors

The Lu Research Group, The University of Texas, Austin 105 E 24th Street, Welch Hall 4.300A, Austin, TX 78712, USA
Interests: DNAzyme; aptamer; functional DNA; upconversion nanomaterials; gold nanoparticles; point-of-care detection; biosensors; DNA nanotechnology; live imaging; chemical biology tools; bioengineering; metal ions; metabolites; biomarkers
Special Issues, Collections and Topics in MDPI journals
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
Interests: CRISPR-based diagnostics; synthetic biosensors; functional nucleic acids; CRISPR-based probes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

DNA-based diagnostics starts with the realization of DNA as the carrier of genetic information and the detection of different pathogens and genetic variants by using the identity of DNAs. Breakthroughs in biotechniques have revolutionized the identification of DNA sequences and led to various sensing platforms. Among these sensing techniques, PCR and antisense hybridization methods are intensively applied for the detection of DNA at the level of single-nucleotide polymorphisms in diagnostics, and have been converted into convenient biosensors.

Beyond their function as carriers of genetic information, structured DNAs that complex with cofactors are identified as having target binding or catalytic functions and, thus, are named functional DNAs. One major type of functional DNA is DNA aptamers, which are considered as the chemical equivalent of antibodies for the specific binding of targets. The target repertoire of aptamers is very broad, ranging from small metabolites to proteins, cells, and tissues. Another major type of functional DNA is analogues of protein enzymes, named deoxyribozymes or DNAzymes, which can catalyze certain chemical reactions. The functional DNAs offer a parallel approach, beyond nucleic acids, to identifying biomarkers in diagnostics.

Recent advances in DNA nanotechnology, including chemically modified functional DNAs (XNAs), DNA logic gate circuits (DNA computation), and DNA-based signal amplification techniques, have further increased the power of DNA-based biosensors for a spectrum of diagnostic applications in biochemical monitoring, point-of-care detection, and live cell imaging.

This Special Issue of Biosensors, entitled “DNA-Based Biosensors for Diagnostics”, aims to provide the most recent progress in the development and application of DNA-based sensing methods. We invite contributions from all researchers in this thrilling field to contribute to the success of this Special Issue.

Dr. Zhenglin Yang
Dr. Jingjing Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • DNA-based biosensors
  • diagnostics
  • biomarkers
  • functional DNAs
  • DNAzymes
  • DNA aptamers
  • DNA nanotechnology

Published Papers

There is no accepted submissions to this special issue at this moment.
Back to TopTop