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8.3
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Journals
Biomolecules
Special Issues
Genetics and Genomics of Gastrointestinal Cancers
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Genetics and Genomics of Gastrointestinal Cancers

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3421

Special Issue Editor

Dr. Alessio Biagioni

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Guest Editor
Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale G.B. Morgagni 50, Florence, Italy
Interests: cancer genetics; gastric cancer; angiogenesis; tumor metabolism; CRISPR gene editing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gastrointestinal cancers comprise a large family of malignancies localized in the esophagus, stomach, liver, pancreas, small and large intestine, rectum, and anus that account for about 5,000,000 new cases per year and almost 3,540,000 deaths worldwide. These very heterogenous histotypes of cancers are characterized by very dissimilar diffusion between Eastern and Western countries and are associated with numerous different factors that influence the epidemiological distribution, including environmental risk factors, prevention strategies, and lifestyles. Casual or inherited mutations in several key genes that regulate cell growth and differentiation and encode the mechanisms responsible for repairing DNA cause the oncogenesis and progression of such malignancies. Mutations are commonly capable of inducing chemoresistance, which is in turn responsible for therapy failure and tumor recurrence.

This Special Issue aims to collect manuscripts that focus on the genetic mutations and peculiarities of gastrointestinal cancers, considering not only the molecular mechanisms but also the clinical implications in terms of prognosis and therapeutic perspectives.

Dr. Alessio Biagioni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastrointestinal cancers
  • genetics
  • genomics
  • mutations
  • chemoresistance

Published Papers (2 papers)

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Research

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13 pages, 8029 KiB  
Article
Functional Proteomic Profiling Analysis in Four Major Types of Gastrointestinal Cancers
by Yangyang Wang, Xiaoguang Gao and Jihan Wang
Biomolecules 2023, 13(4), 701; https://doi.org/10.3390/biom13040701 - 20 Apr 2023
Cited by 1 | Viewed by 1318
Abstract
Gastrointestinal (GI) cancer accounts for one in four cancer cases and one in three cancer-related deaths globally. A deeper understanding of cancer development mechanisms can be applied to cancer medicine. Comprehensive sequencing applications have revealed the genomic landscapes of the common types of [...] Read more.
Gastrointestinal (GI) cancer accounts for one in four cancer cases and one in three cancer-related deaths globally. A deeper understanding of cancer development mechanisms can be applied to cancer medicine. Comprehensive sequencing applications have revealed the genomic landscapes of the common types of human cancer, and proteomics technology has identified protein targets and signalling pathways related to cancer growth and progression. This study aimed to explore the functional proteomic profiles of four major types of GI tract cancer based on The Cancer Proteome Atlas (TCPA). We provided an overview of functional proteomic heterogeneity by performing several approaches, including principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), t-stochastic neighbour embedding (t-SNE) analysis, and hierarchical clustering analysis in oesophageal carcinoma (ESCA), stomach adenocarcinoma (STAD), colon adenocarcinoma (COAD), and rectum adenocarcinoma (READ) tumours, to gain a system-wide understanding of the four types of GI cancer. The feature selection approach, mutual information feature selection (MIFS) method, was conducted to screen candidate protein signature subsets to better distinguish different cancer types. The potential clinical implications of candidate proteins in terms of tumour progression and prognosis were also evaluated based on TCPA and The Cancer Genome Atlas (TCGA) databases. The results suggested that functional proteomic profiling can identify different patterns among the four types of GI cancers and provide candidate proteins for clinical diagnosis and prognosis evaluation. We also highlighted the application of feature selection approaches in high-dimensional biological data analysis. Overall, this study could improve the understanding of the complexity of cancer phenotypes and genotypes and thus be applied to cancer medicine. Full article
(This article belongs to the Special Issue Genetics and Genomics of Gastrointestinal Cancers)
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Review

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16 pages, 832 KiB  
Review
Gastric Cancer Vascularization and the Contribution of Reactive Oxygen Species
by Alessio Biagioni, Sara Peri, Giampaolo Versienti, Claudia Fiorillo, Matteo Becatti, Lucia Magnelli and Laura Papucci
Biomolecules 2023, 13(6), 886; https://doi.org/10.3390/biom13060886 - 25 May 2023
Cited by 4 | Viewed by 1632
Abstract
Blood vessels are the most important way for cancer cells to survive and diffuse in the body, metastasizing distant organs. During the process of tumor expansion, the neoplastic mass progressively induces modifications in the microenvironment due to its uncontrolled growth, generating a hypoxic [...] Read more.
Blood vessels are the most important way for cancer cells to survive and diffuse in the body, metastasizing distant organs. During the process of tumor expansion, the neoplastic mass progressively induces modifications in the microenvironment due to its uncontrolled growth, generating a hypoxic and low pH milieu with high fluid pressure and low nutrients concentration. In such a particular condition, reactive oxygen species play a fundamental role, enhancing tumor proliferation and migration, inducing a glycolytic phenotype and promoting angiogenesis. Indeed, to reach new sources of oxygen and metabolites, highly aggressive cancer cells might produce a new abnormal network of vessels independently from endothelial cells, a process called vasculogenic mimicry. Even though many molecular markers and mechanisms, especially in gastric cancer, are still unclear, the formation of such intricate, leaky and abnormal vessel networks is closely associated with patients’ poor prognosis, and therefore finding new pharmaceutical solutions to be applied along with canonical chemotherapies in order to control and normalize the formation of such networks is urgent. Full article
(This article belongs to the Special Issue Genetics and Genomics of Gastrointestinal Cancers)
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