Glioblastoma: Pathogenetic, Diagnostic and Therapeutic Perspectives

Dear Colleagues,

Glioblastoma (GBM) is a highly aggressive and invasive tumor that targets the central nervous system (CNS), boasting the lowest survival rate among CNS tumors with a median survival time of only 12–15 months. Its treatment protocol involves surgical resection, followed by fractionated radiotherapy and concurrent/adjuvant chemotherapy using temozolomide. Despite these clinical interventions, recurrence is prevalent, occurring in over 80% of cases at the resection cavity's edge within months post-treatment. This high recurrence rate and the tumor's location underscore the pressing need for a deeper understanding of therapeutic strategies.

An enhanced comprehension of GBM's molecular and cellular heterogeneity can not only refine subgroup categorization for precise diagnosis but also pave the way for targeted therapy success. Targeting the Warburg effect presents a promising avenue for GBM treatment due to its metabolic adaptability. Moreover, employing various immunotherapeutic approaches such as checkpoint inhibitors, vaccines, CAR-modified NK or T cells, and oncolytic virotherapy aims to bolster the immune response against GBM. Additionally, efforts to breach the blood–brain barrier (BBB) using nanotherapies (targeting GB cellular receptors or opening the BBB) or non-ionizing energies (high/low-intensity focused ultrasounds) offer potential breakthroughs to overcome current therapy limitations.

This Special Issue aims to delve into the pathophysiological mechanisms driving glioblastoma, uncover potential therapeutic targets, and explore advanced methodologies that hold promise in combating this lethal disease.

Dr. Thi Thu Trang Nguyen
Guest Editor

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• drug delivery methods (TTFields, nanoparticles)
• immunotherapy
• oncolytic virotherapy
• cell metabolism (glycolysis, OXPHOS, fatty acid oxidation)
• epigenetic
• biomarkers
• gene therapy (CRISPR/Cas9)