Epigenetic Mechanisms of Postoperative Cognitive Impairment Induced by Anesthesia and Neuroinflammation
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 126
Special Issue Editor
Interests: sepsis; sepsis therapy; cognitive dysfunction; subarachnoid hemorrhage; inflammation; glucocorticoids
Special Issue Information
Dear Colleagues,
The aim of this Special Issue is to gain a deeper view into the molecular mechanisms of cognitive impairment after surgery, which is a common problem that mainly affects the elderly and can be divided into postoperative delirium and postoperative cognitive dysfunction. Both phenomena are accompanied by neuroinflammation; however, the precise molecular mechanisms underlying cognitive impairment after anesthesia are not yet fully understood. Anesthetics can have a longer-term impact on protein transcription; thus, epigenetic alterations are a possible mechanism. Epigenetic mechanisms may be responsible for long-lasting effects and may implicate novel therapeutic approaches. Studies that focus on the impact of anesthetics on the expression of DNA and histone-modifying enzymes are welcome, as these can affect epigenetic markers, such as methylation, histone acetylation, and histone methylation. As neuroinflammation is generally increased, studies could focus on inflammatory genes (e.g., TNF-alpha, IL-6, or IL1 beta) and genes that are responsible for neuronal development (such as brain-derived neurotrophic factor) could be examined. In addition, studies that focus on the development of novel therapeutic approaches are highly desired.
Dr. Rump Katharina
Guest Editor
Manuscript Submission Information
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Keywords
- cognitive impairment
- postoperative delirium
- postoperative cognitive dysfunction
- neuroinflammation
- DNA methyltransferase
- HDAC. HAT
- epigenetics
- DNA methylation
- histone modification
- RNAi
