Autophagy: From Physiology to Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 117
Special Issue Editor
Interests: autophagy lysosomal pathway (ALP); transcription factor EB, blood–brain barrier permeable drugs; biomaterials; autophagy inducers; animal models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autophagy is a process in which the cell's own structure transports damaged organelles, misfolded proteins and other macromolecules to lysosomes for degradation and reuse through the lysosomal mechanism. Transcription factor EB is believed to be the master regulator of autophagy and lysosomal biogenesis in different disease mechanisms. Although autophagy is closely associated with health, the intricate relationship between autophagy, aging, and disease remains unclear, and the functional role of autophagy and its importance in the physiology of disease needs to be revealed. As such, the goal of this Special Issue is to delve into the pathological implications of autophagy dysregulation and explore how defects in autophagy contribute to the development and progression of human diseases, such as neurodegenerative disorders, cancer, metabolic syndromes, and infectious diseases.
We welcome submissions on a wide range of topics related to autophagy, including the fundamental mechanisms underlying autophagy, the molecular machinery involved and the regulatory pathways that govern autophagic processes, and the molecular and cellular mechanisms by which autophagy dysfunction affects disease pathogenesis.
Dr. Ashok Iyaswamy
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- autophagy
- cellular homeostasis
- autophagy-related genes (ATGs)
- regulatory pathways
- TFEB, TFE3, PPARa, nutrient recycling
- protein quality control
- tissue-specific autophagy
- neurodegenerative diseases
- autophagy modulators
- autophagy biomarkers
- autophagy dysregulation
- Alzheimer’s disease
- Parkinson’s disease
- multiple sclerosis
- stroke
- MTOR
- cancer
