Special Issue "Macrophages in Cardio-Renal Diseases"
Deadline for manuscript submissions: 30 November 2023 | Viewed by 181
2. Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Interests: cardiovascular disease; atherosclerosis; inflammation; macrophage
Macrophages play a significant role in cardio-renal diseases, including atherosclerosis, heart failure, hypertension, and chronic kidney disease. They contribute to the development and progression of these conditions through inflammation, tissue remodeling, and fibrosis. In atherosclerosis, macrophages form lipid-laden foam cells within arterial walls, thus leading to plaque formation. They promote myocardial inflammation and fibroblast activation, contributing to adverse remodeling in heart failure. Macrophages also play a role in hypertension by causing renal inflammation and vascular dysfunction. In chronic kidney disease, macrophages contribute to renal inflammation, fibrotic remodeling, and impaired tissue repair. Targeting macrophage activities and interactions holds promise for therapeutic interventions in cardio-renal diseases, offering opportunities to mitigate inflammation, improve vascular function, and preserve renal integrity. Therefore, this issue will focus on recent findings uncovering new aspects of macrophage biology in cardio-renal diseases.
Dr. Satyesh K. Sinha
Dr. Yuchen Wang
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- cardiovascular disease and macrophages
- macrophage-mediated inflammation
- macrophage phenotypes
- macrophage senescence
- macrophage proliferation and survival
- macrophages and lipid metabolism