Iron Metabolism in Cancer
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 99
Special Issue Editors
Interests: liver tumors; iron metabolism; tumor microenvironment; tumor metabolism; cholangiocarcinoma; cancer stem cells; macrophages
Interests: liver tumors; iron metabolism; tumor microenvironment; iron homeostasis; cholangiocarcinoma; macrophages; erythropoiesis
Special Issue Information
Dear Colleagues,
It has been shown that tumor cells display unique metabolic and bioenergetic features, including deregulation in iron metabolism. Several studies have shown that the reprogramming of iron metabolism is a key function for a cancer cell and that the disruption of iron homeostasis may play an important role in cancer development and progression. This Special Issue will provide insights into changes occurring in iron metabolism during carcinogenesis, with a particular focus on the influence of the microenvironment on it. In fact, an increasing number of studies support the role of the surrounding tumor microenvironment in regulating tumor cell metabolic plasticity. Moreover, a general metabolic rewiring can be observed in cancer cells upon the reprogramming of iron metabolism, favoring tumor development, survival, and metastasis development. Hence, the Special Issue will also aim to explore how dysregulation in iron metabolism may influence the other metabolic pathways in tumor cells, highlighting the importance of targeting iron metabolism as a novel therapeutic strategy for tumors.
Dr. Margherita Correnti
Dr. Stefania Recalcati
Dr. Elena Gammella
Guest Editors
Manuscript Submission Information
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Keywords
- iron metabolism
- cancer
- microenvironment
- tumor metabolism
- metabolic rewiring
- tumor plasticity
