Small RNA Signatures in Neurological Disorders: Insights from Developmental Biology and Neuroscience
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 149
Special Issue Editor
Interests: inflammatory brain diseases; miRNA; ncRNA; ceRNA; biomarker; acupuncture; neuroscience; neurobiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Small RNAs are a type of non-coding RNA (ncRNA) molecule that are ~200 nucleotides in length. They are involved in regulating the translation of target RNAs through epigenetic modification, RNA–RNA interaction, the RNA interference, etc. These include microRNAs (miRNAs), transfer RNA-derived RNAs (tDRs), Piwi-interacting RNAs (piRNAs) and long intergenic non-coding RNAs (lincRNAs). They down-regulate gene expression, playing a major role in biological pathways such as differentiation, proliferation, metastasis and apoptosis. Furthermore, they have been reported in bodily fluids such as plasma, serum, urine, saliva and cerebrospinal fluids (CSFs). The use of next-generation sequencing (NGS) in small RNA detection has shed light on the key role of small RNAs in healthy and disease conditions and accelerated the profiling and discovery of pathophysiological mechanisms. The study of this small RNA’s signature in different bodily fluids is expanding to various fields, including developmental biology and neuroscience.
To gain insights into the distribution and signature of small RNA in bodily fluids, this Special Issue will focus on cutting-edge research on small RNA signatures in neurological disorders. Studies focusing on basics as well as those based on applications are welcome.
Dr. Seung-Nam Kim
Guest Editor
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Keywords
- small RNAs
- miRNA
- piRNA
- lincRNA
- ceRNA
- developmental biology
- neuroscience
- neurobiology
- neurological disorder
- serum
- plasma
- cerebrospinal fluids
