Lipid and Lipoprotein Metabolism in Human Health and Diseases—the 2nd Edition

Dear Collegues,

Lipids are essential components of cellular membranes and lipoproteins. Lipids play many essential roles in cellular functions, including cellular barriers, membrane matrices, signaling pathways and energy storage.

Lipid and lipoprotein metabolism represent a complex set of chemical reactions involving liver, bowel, and endothelial compartments. Specific proteins and enzymes are involved in this process and, when deficient, they cause human diseases (e.g., familial hypercholesterolemia (FH) or familial chylomicronemia syndrome (FCS)).

Since the 1950s, lipids have been extracted from cells or tissues and total lipid extracts have been analyzed by chromatography and mass spectrometry. Over the years, the detailed study of lipid and lipoprotein metabolism has led to greater knowledge of the pathophysiological mechanisms of dyslipidemias. Furthermore, the identification of new therapeutic targets has allowed for the treatment of pathologies that had been ignored until a few years ago (e.g., PCSK9, ANGPTL-3, ApoCIII and MTP inhibition).

New perspectives are emerging from novel laboratory approaches, in particular omics studies. The results of these studies are promising in identifying novel biomarkers that will help in the diagnosis, prognosis and treatment of human diseases (e.g., cancer and atherosclerotic vascular diseases). Moreover, a promising application is the characterization of endpoints in clinical trials, which remains a major issue in drug development.

The aim of the Special Issue is to give an update on new evidence in studies on lipid metabolism and multi-omics evaluations and to clarify the molecular features of human disease, particularly in hereditary lipid disorders. The present Special Issue is addressed towards basic and clinical research.  Reviews and original research articles are welcome. The topics included in the Special Issue are the following:

• The role of lipids in various physiological processes and pathophysiological mechanisms of human disease;
• The evaluation of lipidome modifications following pharmacological intervention;
• Novel laboratory approaches (multi-omics) to human disease, in particular lipid disorders and atherosclerosis.

Dr. Ilenia Calcaterra
Guest Editor

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• lipoprotein
• lipid metabolism
• lipidome
• lipidomics
• mass spectrometry
• hereditary lipid disorders
• familial hypercholesterolemia
• omic
• metabolomic
• genomic

• Lipid and Lipoprotein Metabolism in Human Health and Diseases in Biomedicines (5 articles)