Molecular Research and Treatment of Pediatric Dermatology

Dear Colleagues,

The skin, as an interface between the organism and the environment, is a vital organ with multiple functions for the organism, including the barrier function and the immune function. Changes in epidermal differentiation and lipid composition lead to an altered skin barrier, which allows the entry of environmental allergens, immunological reactions, and inflammation. Changes in the skin barrier may be essential for the pathogenesis of contact dermatitis, ichthyosis, psoriasis, and atopic dermatitis. Similarly to lung and gut mucosal barriers, the skin implements a well-coordinated immune surveillance system with the synergistic action of epithelial and immune cells. Such a system permits an adequate immune response against trauma, toxins, and infectious agents, while maintaining self-tolerance, preventing allergy, and inhibiting autoimmunity.

There is a very close relationship between the skin barrier and the immune system. It is well known that the immune dysregulation of the innate and adaptive immunity may lead to chronic skin disorders which can occur from the first years of life. However, little is currently known about systemic inflammation in recent-onset skin diseases of childhood.

The aim of this Special Issue is to collect emerging research in the field of topical and systemic biomedicines in Pediatric Dermatology. The spectrum of potential studies is very broad, but therapeutic applications for the treatment of immune-mediated pediatric skin diseases are welcomed. In addition, submissions of original research or review articles are welcome, with topics including new compounds and products, intervention in known pathways or the investigation of new ones, identification of new molecular targets, innovative therapies, and new formulations and delivery systems.

Dr. Vito Di Lernia
Guest Editor

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• psoriasis
• atopic dermatitis
• skin
• need
• diagnosis
• treatment
• drug
• therapy
• biological