Involvement of Free Radicals in Health and Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 74
Special Issue Editor
Interests: aging and oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Among the systems that generate free radicals in living beings, it is worth highlighting the mitochondrial transport chain, the metabolism of fatty acids in peroxisomes, reactions catalyzed by cytochrome P450, and the processes of phagocytic combustion of leukocytes.
The production of free radicals in healthy organisms is relatively balanced by antioxidant defense systems, but when the balance shifts toward the formation of free radicals, oxidative stress is generated, considered an alteration of the balance between prooxidant and antioxidant species, in favor of the former. This can be caused by excess prooxidant substances (exposure to ionizing radiation, intense ultraviolet radiation, toxins, psychological or physical stress, and certain pathologies), by a deficiency of antioxidant agents (deficient enzyme systems in newborns, aging, etc.), or both factors at the same time. The action of free radicals on cellular structural constituents produces continuous internal aggression, which threatens the integrity of all biomolecules. The pathological consequences will depend on the type of cellular constituent that is most damaged. Almost all organic or inorganic molecules found in living cells can be considered oxidizable substrates, such as proteins, lipids, carbohydrates and DNA molecules.
Therefore, the study of the effects of free radicals in both health and disease, as well as the mechanisms necessary to combat them, is of great interest.
Dr. Laura Lõpez-Pingarrõn
Guest Editor
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Keywords
- free radicals
- mitochondrial
- peroxisomes
- cytochrome P450
