Interaction between Liver and Adipose Tissues

Dear Colleagues,

In the body, the liver and adipose tissues are two important organs that interact to regulate energy balance and metabolic processes. It is well known that obesity causes steatohepatitis. In contrast, the liver may also affect the development of obesity. In this Special Issue, we accept new research articles or review articles focusing on the interaction between the liver and adipose tissues under normal or pathophysiological conditions. The topics may include, but are not limited to, the following aspects:

• Fat mobilization to the liver: effects of adipolipolysis on liver fat accumulation and steatohepatitis; on fat trafficking proteins, including CD36, MTTP, apoB, and VLDL synthesis and secretion; and on liver phospholipid and cholesterol synthesis for membranous organelles and the cytoplasm membrane during liver regeneration.
• Hormone and extracellular vesicles (exosomes): Adipokines like adiponectin on the liver; hepatokines like FGF21 on adipose tissues; other hormones, like growth hormones, thyroid hormones, or glucocorticoids, on the interaction between the liver and adipose tissues; and exosome connections between adipose tissues and the liver.  
• Ethanol metabolism: Effects of ethanol on adipose lipolysis, liver fatty acid oxidation, and liver lipogenesis; effects of adipogenesis on ethanol metabolism and alcoholic steatohepatitis.
• Bile acid signaling: Effects of adipose tissues on liver bile acid synthesis; bile acid receptors including FXR and TGR5 on obesity.
• Glucose homeostasis: Effects of adipose tissues on glycogen storage in the liver; effects of liver gluconeogenesis on the development of obesity; interactions between the liver and adipose tissues during diabetes.

Dr. Yongke Lu
Guest Editor

Manuscript Submission Information

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• ethanol
• bile acid
• gluconeogenesis
• steatosis
• obesity
• fatty acid oxidation
• extracellular vesicles