Bone Regeneration, Osteoclastogenesis, Osteoporosis and Osteoarthritis

Dear Colleagues,

Load-bearing joints like the knee, hip, ankle, temporomandibular joint (TMJ), and spine perform the specialized functions of mechanical loading, energy dissipation, and lubrication, and are frequently exposed to high-stress conditions. These structurally specific joints undergo the continuous remodeling of bone to maintain optimal bone mass, integrity, and strength. The symmetry between bone formation and bone resorption can be disrupted by changes in physiological conditions, traumatic mechanical alterations like post-traumatic osteoarthritis, and genetic mutations such as Ehlers–Danlos syndrome (EDS) and achondroplasia, causing joint breakdown via osteoarthritis or bone diseases like osteoporosis. Furthermore, changes in bone morphology are considered a hallmark of advanced osteoarthritis. Complications resulting from these conditions affect patients’ quality of life, contribute to significant morbidity and joint degeneration, and cause impaired joint function. Current treatments involving joint replacement come with their own underlying issues. Therefore, it is essential for us to understand the underlying molecular mechanisms and complex interactions of bone regeneration and osteoclastogenesis, which can help us to diagnose disease early, and provide therapeutic targets for intervention at multiple stages.

Numerous therapeutic strategies for treating bone diseases affecting these load-bearing joints have been identified and proposed. These include the use of tissue engineering, engineered and autologous bone grafts, and gene therapy interventions, to name but a few. The following topics are of interest to this Special Issue:

1. Molecular mechanisms underlying bone regeneration and bone resorption;
2. Molecular mechanisms associated with osteoporosis that may serve as therapeutic targets;
3. Identification of new therapeutic targets in osteoclastogenesis for the treatment of disease;
4. Tissue-engineering-based solutions for promoting bone regeneration.

Dr. Prashant Chandrasekaran
Guest Editor

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• bone regeneration
• bone resorption
• osteoarthritis
• osteoporosis
• tissue engineering
• osteoclastogenesis
• gene therapy
• temporomandibular joint