The Role of Regulatory T Cells in Aging Processes
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 226
Special Issue Editor
Special Issue Information
Dear Colleagues,
The immune system is an exquisitely regulated network that allows the development of defense mechanisms against foreign antigens and tolerance towards self-antigens. Regulatory T cells prevent excessive reactions from T cells as a response to pathogens by modulating both the innate and adaptive immune system whilst maintaining unresponsiveness to self-antigens contributing to immune tolerance. During aging, the immune system undergoes different changes that result in decreased immune competence and higher susceptibility to illness. Regulatory T cells and their functions are also affected by age-related changes; however, to date, there is not a clear picture of the causes and consequences of these modifications.
The focus of this Special Issue is to gain insight into the latest findings on regulatory T cells in aging individuals. Understanding the modifications undergone by these cells may help to identify the origin of regulatory T-cell-derived diseases, which are increased with age.
Dr. Lourdes Rocamora-Reverte
Guest Editor
Manuscript Submission Information
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Keywords
- regulatory T cells
- aging
- inhibitory molecules
- TCR repertoire
- cancer
- vaccination
- autoimmunity
- chronic inflammation
