Application and Nanotechnologies in 3D Bioprinting Models for Personalized Cancer Treatment

Dear Colleagues,

In cancer research, the structural and functional complexity of cancer biology represents an obstacle to efficiently combatting the development and evolution of cancer-related diseases. The tissue-specific microenvironment and its rheological properties are among the few hurdles encountered while exploring personalized treatments for cancer patients. Therefore, accurate and reproducible biological platforms may better resemble the complexity of cancer biology, ranging from its structure as 3D tissue to its function and evolution. In this regard, 3D bioprinting models have the great potential to investigate cancer biology in a more realistic and reproducible manner, strengthening the potential of its clinical translation. Shedding lights on some of the still-unclear mechanisms essential for supporting the tissue’s mechanical properties and their molecular-activated pathways involved in the interaction of tumor cells and its microenvironment might be key to more deeply understanding the establishment and evolution of cancer-related disease. The use of advanced technologies to generate 3D bioprinting platforms and the use of these biological systems may assist researchers and industries in their efforts to study cancer progression. The application of new technologies and materials, including bioinks, crosslinking techniques, and hydrogels in 3D bioprinting models, will serve as prognostic and interventional tools for the development of new therapeutics or the repurposing of current ones in a more personalized manner. The combination of several disciplines applied to 3D bioprinting, ranging from tissue engineered, advanced materials to molecular biology, represents a robust and faithful means of carrying out future clinical trials.

Dr. Sabina Pozzi
Guest Editor

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• 3D bioprinting technologies
• 3D bioprinting cancer models
• bioinks
• hydrogels
• molecular and cell biology
• clinical trials
• personalized medicine