The Role of MicroRNAs in Adult Skeletal Muscle
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 83
Special Issue Editor
Special Issue Information
Dear Colleagues,
MicroRNAs (miRNAs) are small non-coding RNAs that canonically repress gene expression at the post-transcriptional level by binding to complementary sequences on target mRNAs. MiRNAs act as part of a large ribonucleoprotein complex, known as an RNA-induced silencing complex (RISC), that can lead to mRNA degradation (e.g., decapping and deadenylation) and/or translation repression (e.g., preventing translation initiation). Computational and experimental analyses indicate that miRNAs target components of virtually every cellular process; however, the global inhibition of miRNA function in adult skeletal muscle (i.e., the deletion of core miRNA biogenesis proteins) is often indistinguishable from their wild-type counterparts. Debates surrounding if miRNAs have extended half-lives in these knockout models or if miRNAs are partly regulated by a Dicer-independent mechanism are still under investigation. This Special Issue focuses on the mechanisms by which miRNAs regulate adult skeletal muscle biology. We invite miRNA studies to investigate various aspects of adult skeletal muscle regulation, including (but not limited to) muscle regeneration, aging, and adaptation to different stimuli.
Dr. Ivan J. Vechetti
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- skeletal muscle
- miRNAs
- regeneration
- aging
- atrophy
- hypertrophy
