Molecular Mechanisms of Host-Bacterial Pathogen Interactions: Novel Promising Drug Targets—2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 243

Special Issue Editor

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Guest Editor
IBB-Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Técnico, Lisbon, Portugal
Interests: microbiology; antimicrobial agents; immunotherapy and vaccines against bacterial infections; nosocomial infections; Cystic Fibrosis
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Special Issue Information

Dear Colleagues,

Infectious diseases still constitute a threat to animal and human life. The increase in antibiotic resistance in a multitude of bacterial infectious diseases highlights the need for new targets for drug development. In particular, bacterial pathogens have evolved multiple mechanisms that interfere with or stimulate a variety of host-cell responses in order to invade, survive, and proliferate within their hosts. The knowledge of how pathogens interact with their hosts can be the basis for the development of novel therapeutic approaches for treatment and/or prevention of bacterial infections. Some promising bacterial targets have been already described, such as targets that regulate virulence factor expression and/or secretion and targets that modulate host-cells defense pathways. However, the identification of these drug targets is still complex, requiring an extensive knowledge about the complex interplay between the pathogen and the host. One of the current strategies that enable these studies is host-pathogen interactome analysis.

We cordially invite investigators within this field of study, to submit original research or review articles about the molecular mechanisms of specific host-bacteria interactions, and their potential as targets for drug discovery. 

Dr. Sílvia A. Sousa
Guest Editor

Manuscript Submission Information

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  • host-pathogen interactome
  • cell-to-cell communication during host–pathogen infection
  • bacteria-epithelium interaction
  • bacterial targets that regulate virulence factor expression and/or secretion
  • bacterial targets that modulate host-cells defense pathways

Published Papers

This special issue is now open for submission.
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