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Biology
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New Advances and Insights in Osteoarthritis
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New Advances and Insights in Osteoarthritis

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2683

Special Issue Editors

Prof. Dr. Magali Cucchiarini

E-Mail Website
Guest Editor
Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrbergerstr. Bldg 37, D-66421 Homburg, Saar, Germany
Interests: molecular gene therapy; human regenerative medicine; tissue engineering; musculoskeletal research; stem cells
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Henning Madry

E-Mail Website
Guest Editor
Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrbergerstr. Bldg 37, D-66421 Homburg, Saar, Germany
Interests: human musculoskeletal disorders; clinical orthopaedics; animal models; human regenerative medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Osteoarthritis is a severe disease that affects various tissues of the musculoskeletal system (articular cartilage, bone, meniscus, and tendons/ligaments), and for which there is no definitive cure. None of the injured tissues in OA are capable of fully healing by themselves due to their restricted and/or inappropriate intrinsic ability to spontaneously repair and regenerate. A variety of clinical treatments are available to manage OA, yet they cannot restore the natural tissue structures in their original biological and mechanical activities in patients, highlighting the crucial need for a better understanding of the disease itself and for improved therapeutic options to trigger the healing mechanisms in sites of tissue injury. The goal of this Special Issue is to provide an overview of the most recent advances and insights in OA that may be employed to better manage disease in affected individuals in the future.

Prof. Dr. Magali Cucchiarini
Prof. Dr. Henning Madry
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoarthritis
  • pathomechanisms, epidemiology
  • biomarkers
  • genetics, epigenetics
  • disease modelling, imaging
  • tissue repair, remodelling
  • regenerative OA medicine
  • gene and cell therapy
  • tissue engineering

Published Papers (2 papers)

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Research

12 pages, 905 KiB  
Article
Effects of Terpenes on the Osteoarthritis Cytokine Profile by Modulation of IL-6: Double Face versus Dark Knight?
by Giacomo Farì, Marisa Megna, Salvatore Scacco, Maurizio Ranieri, Maria Vittoria Raele, Enrica Chiaia Noya, Dario Macchiarola, Francesco Paolo Bianchi, Davide Carati, Antonio Gnoni, Alessio Danilo Inchingolo, Erda Qorri, Antonio Scarano, Antonio Scacco, Roberto Arrigoni and Biagio Rapone
Biology 2023, 12(8), 1061; https://doi.org/10.3390/biology12081061 - 28 Jul 2023
Cited by 3 | Viewed by 785
Abstract
Background: Hemp seed oil and terpenes are emerging as a dietary supplement and complementary therapy for patients suffering from knee osteoarthritis (KOA). However, the mechanisms and effects induced by these molecules on inflammatory cytokines are not yet fully understood. The aim of this [...] Read more.
Background: Hemp seed oil and terpenes are emerging as a dietary supplement and complementary therapy for patients suffering from knee osteoarthritis (KOA). However, the mechanisms and effects induced by these molecules on inflammatory cytokines are not yet fully understood. The aim of this study was to evaluate the changes in the cytokine IL-1β, IL-1α, IL-2, IL-6, and TNF-α levels from two oral hemp seed oil-based dietary supplements, of which only one included the addition of terpenes, in a population of KOA patients. Methods: Sera from venous blood samples were collected from thirty-eight patients who were divided into two subgroups. The control group underwent a 45-day treatment with a dietary supplement containing only hemp seed oil, while the treatment group assumed a hemp seed oil and terpene-based dietary supplement for the same number of days. A Bio-Plex Human Cytokine assay was performed by a customized human cytokine five-plex panel for IL-1β, IL-1α, IL-2, IL-6, and TNF-α. Patients were evaluated before the beginning of the treatment (T0) and soon after it (T1). Results: No measurable levels of IL-2 and TNF-α were found in any of the subjects. Low levels of IL-1β were found, which were significantly decreased in the treatment group. No change in IL-1α levels was observed, while treated patients had a significant increase in IL-6 levels. Conclusions: Hemp seed oil and terpene treatment modified the IL-1β and IL-6 levels, counteracting KOA inflammation in this way. In this study, IL-6 revealed its new and alternative action, since it is traditionally known as a pro-inflammatory factor, but it recently has been found to have anti-inflammatory activity in the muscle-derived form, which is the one it assumes as a myokine when activated by terpenes. Full article
(This article belongs to the Special Issue New Advances and Insights in Osteoarthritis)
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23 pages, 4267 KiB  
Article
Molecular Characterization of Secreted Factors and Extracellular Vesicles-Embedded miRNAs from Bone Marrow-Derived Mesenchymal Stromal Cells in Presence of Synovial Fluid from Osteoarthritis Patients
by Enrico Ragni, Carlotta Perucca Orfei, Federico Valli, Luigi Zagra and Laura de Girolamo
Biology 2022, 11(11), 1632; https://doi.org/10.3390/biology11111632 - 8 Nov 2022
Cited by 2 | Viewed by 1401
Abstract
Bone marrow-derived mesenchymal stromal cells (BMSCs)-based therapies show a great potential to manage inflammation and tissue degeneration in osteoarthritis (OA) patients. Clinical trials showed the ability to manage pain and activation of immune cells and allowed restoration of damaged cartilage. To date, a [...] Read more.
Bone marrow-derived mesenchymal stromal cells (BMSCs)-based therapies show a great potential to manage inflammation and tissue degeneration in osteoarthritis (OA) patients. Clinical trials showed the ability to manage pain and activation of immune cells and allowed restoration of damaged cartilage. To date, a molecular fingerprint of BMSC-secreted molecules in OA joint conditions able to support clinical outcomes is missing; the lack of that molecular bridge between BMSC activity and clinical results hampers clinical awareness and translation into practice. In this study, BMSCs were cultured in synovial fluid (SF) obtained from OA patients and, for the first time, a thorough characterization of soluble factors and extracellular vesicles (EVs)-embedded miRNAs was performed in this condition. Molecular data were sifted through the sieve of molecules and pathways characterizing the OA phenotype in immune cells and joint tissues. One-hundred and twenty-five secreted factors and one-hundred and ninety-two miRNAs were identified. The combined action of both types of molecules was shown to, first, foster BMSCs interaction with the most important OA immune cells, such as macrophages and T cells, driving their switch towards an anti-inflammatory phenotype and, second, promote cartilage homeostasis assisting chondrocyte proliferation and attenuating the imbalance between destructive and protective extracellular matrix-related players. Overall, molecular data give an understanding of the clinical results observed in OA patients and can enable a faster translation of BMSC-based products into everyday clinical practice. Full article
(This article belongs to the Special Issue New Advances and Insights in Osteoarthritis)
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