Inflammasome Biology and Molecular Pathology
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".
Deadline for manuscript submissions: closed (15 October 2022) | Viewed by 1311
Special Issue Editor
Special Issue Information
Dear Colleagues,
Inflammasomes are cytosolic sensors that detect microbial molecules and endogenous danger signals to promote inflammation. When triggered, inflammasomes recruit and activate caspase-1 or caspase-11, and its human homologs caspase-4 and 5. Active caspase-1 cleaves pro-IL-1b and pro-IL-18 to mature, secreted forms. Additionally, caspase-1 or 11 cleave gasdermin D (GSDMD), liberating an N-terminal pore-forming domain (PFD) to promote pyroptosis, a form of lytic cell death. The GSDMD-PFD inserts into the plasma membrane and forms large pores that facilitate the release of IL-1b and other small molecules, and subsequently drives plasma membrane rupture (PMR), permitting the release of damage-associated molecular patterns (DAMPs). While inflammasomes can play a protective role against various infections, the hyperactivation or dysregulation of inflammasomes is associated with a number of immunopathologies, such as septic shock, inflammatory bowel disease, type I and II diabetes, and spontaneous allelic mutation-associated inflammatory disorders. To comprehend disease pathogenesis with the objective of novel therapeutic development, it is imperative to first understand the molecular and physiological roles of immune sensors during infection. Recent advances in the field of inflammasome biology suggest roles for inflammasomes in multiple cell processes to mediate defense or inflammatory pathology. In this Special Issue on inflammasome biology and molecular pathology, we solicit original research and review articles that address the molecular mechanisms of inflammasome activation, inflammasome-associated defense, pathogenesis, and therapeutics.
Dr. Youssef Aachoui
Guest Editor
Manuscript Submission Information
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Keywords
- inflammasome
- pyroptosis
- cell-specific inflammasome
- inflammatory caspases
- gasdermin D
- apoptosis
- defense against infection
- inflammatory pathology
