Bone Cell Biology
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 1286
Special Issue Editors
Interests: cellular and molecular medicine; bone; osteoclast; osteoblast; osteocyte; inflammation
2. Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Interests: Graves’ disease; hyperthyroidism; GD extrathyroidal manifestations; thyroid autoimmunity; thyroid disease; Graves’ orbitopathy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bone remodeling is directly coordinated by three skeletal cell types: osteoclasts, osteoblasts and osteocytes for the removal of old bone and formation of new bone. As bone remodeling is a complex and delicate process mediated by all skeletal cells, the disfunction of cell–cell communications can lead to an imbalance and related diseases. Therapeutic approaches for bone diseases predominantly relieve symptoms and improve bone structural features, while there has not been an established therapy to realize longer-acting bone mass and density maintenance while decreasing the side effects. The current challenge is to understand the functional interactions between molecular networks underying cell–cell communications integrated by cell signaling, and also how the genomic architecture is changed in health and disease. This journal publishes the outstanding progress and novel understanding relating bone biology. The journal highlights breakthrough discoveries in basic studies related to bone physiology and pathology. Submissions are favored regarding basic studies on bone development and metabolism in its related diseases. In particular, this Special Issue focuses on mechanistic studies showing multi-omics data integration including epigenetics, transcriptomics and/or proteomics.
Dr. Yohei Abe
Dr. Giulia Lanzolla
Guest Editors
Manuscript Submission Information
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Keywords
- osteoclast
- osteoblast
- osteocyte
- bone density
- macrophage
- RANK
- transcription factor
- cell signaling
