Tumor Microenvironment of Ovarian Cancer: Role of Extracellular Matrix
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 1854
Special Issue Editors
Interests: ovarian cancer; tumor microenvironment; organoids; biomarker discovery; drug discovery
Interests: ovarian cancers; drug discovery; anti-cancer molecules
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue focuses on the tumor microenvironment of ovarian cancer with an emphasis on the extracellular matrix component. Ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer-related deaths among US women. Despite recent advances in chemotherapy, most patients develop chemoresistance and succumb to the disease. The complex and highly heterogenous microenvironment of ovarian cancer is a key factor in chemoresistance. Hence, understanding the ovarian tumor microenvironment and its components, such as cells, extracellular matrix proteins, and growth factors, holds tremendous potential for the design of novel therapies.
The extracellular matrix consists of a number of proteins which play a crucial role in tumor cells invasion and dissemination to the peritoneal cavity. In addition to the protein components, the extracellular matrix is regulated by conditions such as hypoxia, exposure to ovulatory fluid, etc., all of which play a role in the interactions between tumor cells and extracellular matrix.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: cellular models (3D organoids models, co-cultures, spheroids), response to chemotherapy, drugs targeting the tumor microenvironment. We look forward to receiving your contributions.
Dr. Amrita Salvi
Dr. Joanna E. Burdette
Guest Editors
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Keywords
- ovarian cancer
- tumor microenvironment
- immune therapy
- 3D organoids
- extracellular matrix
- PARP inhibitors
- chemoresistance
- fallopian tube
- cancer stem cells
- metastasis
