Recent Advances in Molecular Allergology
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 1813
Special Issue Editor
Special Issue Information
Dear Colleagues,
Progress in molecular biology over the last decades enabled the identification and characterization of the allergenic molecules of the most important allergen sources. The availability of natural or recombinant single allergens is the basis for component-resolved diagnosis, which enables a better understanding of the sensitization patterns of allergic individuals. Especially in the case of cross-reactive allergens, knowledge of the primary source of sensitization is necessary to offer patients targeted therapy. Currently, allergen immunotherapy (AIT) is the only curative treatment for IgE-mediated allergies. If used at an early stage of the disease, it can significantly improve disease progression. However, the risk of adverse reactions is a concern of AIT. To avoid undesirable side effects that lead to treatment discontinuation, one possibility is to use allergen derivatives for AIT that have reduced IgE-binding capacity, but preserved T-cell epitopes to elicit an immune response. This requires that the allergens are known and the IgE-binding as well as T-cell epitopes are characterized.
The aim of this Special Issue is to bring together the latest experimental and theoretical results from experts who are identifying or characterizing allergens, or modifying them so that they can be potential candidates for use in AIT. This Special Issue will include original research articles and state-of-the-art reviews discussing recent advances in both basic and animal model research.
Dr. Marianne Raith
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- allergen identification
- allergen characterization
- cross-reactive allergens
- allergen immunotherapy
- IgE-binding epitopes
- T-cell epitopes
- allergen modification
