Molecular Basis of Bone Homeostasis and Skeletal Diseases
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 1088
Special Issue Editor
2. Department of Medicine, Loma Linda University, Loma Linda, CA 92354, USA
Interests: bone formation; bone resorption; osteoclast; osteoblast; osteoclast differentiation; osteoclast dysfunction; osteoblast differentiation; osteoblast activity; osteoprogenitor; coupling factor; osteoporosis; bone homeostasis; soluble factor; extracellular vesicle; lysosome; exocytosis; hormone; signal pathways; anti-resorption; small molecular inhibitor
Special Issue Information
Dear Colleagues,
Bone homeostasis involves both processes of osteoclast-mediated bone resorption and osteoblast-mediated bone formation. In physiological conditions, bone resorption is coupled with bone formation to maintain bone homeostasis. The destruction of bone tissue by active osteoclasts facilitates growth factor release from resorbed bone matrices, resulting in increased osteoblast proliferation as well as differentiation and bone formation. There are several regulatory factors that mediate osteoclast and osteoblast differentiation and activity. The deficiency or mutation of those factors could cause osteopetrosis or osteoporosis. Recently, there has been increasing interest in the identification of novel gene mutations associated with skeletal diseases and small molecular inhibitors that regulate osteoclast and osteoblast function, and the generation of new humanized mouse models. While significant advancements have been made, these relatively new fields of research are rapidly expanding. For this Special Issue, we invite researchers to contribute with either original research (both in vivo or in vitro studies) or review articles focusing on the molecular basis of bone homeostasis and skeletal diseases (in mice or in humans) in addition to the identification of new therapeutic agents that target osteoclast function or osteoblast activity.
Dr. Weirong Xing
Guest Editor
Manuscript Submission Information
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Keywords
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osteoclast
- osteoblast
- bone
- skeletal disease
- bone formation
- bone resorption
- osteoporosis
- osteopetrosis
- human genetics
- mouse genetics
